INTERACTIONS BETWEEN GROWTH-HORMONE AND DEXAMETHASONE IN SKELETAL GROWTH AND BONE-STRUCTURE OF THE YOUNG-MOUSE
INTERACTIONS BETWEEN GROWTH-HORMONE AND DEXAMETHASONE IN SKELETAL GROWTH AND BONE-STRUCTURE OF THE YOUNG-MOUSE
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DOI：
10.1007/bf00334491
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发表时间：
1992-10-01
影响因子：
4.2
通讯作者：
SILBERMANN, M
中科院分区：
文献类型：
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作者：
ALTMAN, A;HOCHBERG, Z;SILBERMANN, M
本研究调查了生长激素（GH）和糖皮质激素对幼鼠骨骼生长和骨结构的相互作用。本研究的目的是检验 GH 是否可能预防地塞米松 (Dex) 对骨骼生长和骨化部位造成的损伤。从 3-7 周龄开始，给予雌性 ICR 小鼠 4 周，给予 Dex (1 mg/kg) 和或不含大鼠 GH (rGH) 或牛 GH (bGH)，1 mg/kg。对胫骨、肱骨和椎骨进行形态测量和生物化学分析。通过小鼠体重、胫骨长度和肱骨蛋白质含量确定的生长被发现受到地塞米松的影响。 rGH 或 bGH 可以防止这种情况发生。地塞米松可降低骨骺生长板宽度、骨小梁体积、皮质骨宽度、矿物质骨含量以及碱性和酸性磷酸酶活性。 rGH 或 bGH 可以预防这些情况。本研究的结果表明，在小鼠中，生长激素可以减少甚至避免高剂量糖皮质激素治疗造成的骨骼生长中的一些病理特征。
The present study investigated the interactions of growth hormone (GH) and glucocorticoid on skeletal growth and bone structure in young mice. The purpose of this study was to examine the possible prevention by GH of the damage inflicted by dexamethasone (Dex) at sites of skeletal growth and ossification. Dex (1 mg/kg) with or without rat GH (rGH) or bovine GH (bGH), 1 mg/kg, was given for 4 weeks, from age 3-7 weeks, to female ICR mice. Tibiae, humerus, and vertebrae were analyzed morphometrically and biochemically. Growth, as determined by the mouse weight, tibial length, and humerus protein content was found to be compromised by dexamethasone. This was prevented by rGH or bGH. The epiphyseal growth plate width, trabecular bone volume, cortical bone width, mineral bone content, and alkaline and acid phosphatase activity were decreased by dexamethasone. These were prevented by rGH or by bGH. The findings of the present study suggest that in the mouse, GH can decrease or even avoid some of the pathological features in growing bones inflicted by high-dose glucocorticoid treatment.