LOSS OF CIRCADIAN-RHYTHM IN SLEEP-WAKEFULNESS CYCLE IN RAT BY SUPRACHIASMATIC NUCLEUS LESIONS
LOSS OF CIRCADIAN-RHYTHM IN SLEEP-WAKEFULNESS CYCLE IN RAT BY SUPRACHIASMATIC NUCLEUS LESIONS
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DOI：
10.1016/0006-8993(75)90574-0
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发表时间：
1975-01-01
期刊：
影响因子：
2.9
通讯作者：
KAWAMURA, H
中科院分区：
文献类型：
--
作者：
IBUKA, N;KAWAMURA, H
暴露于具有正常昼夜周期的环境照明的大鼠在光照时间1、6期间表现出每天睡眠的更大部分。Stephan和Zucker 7证明，大鼠视交叉上核（SCN）的双侧损伤永久消除了饮酒行为和运动活动的昼夜节律，这些行为和活动在损伤前的黑暗时间内明显更频繁。摩尔和伦恩5描述了这种现象的可能解剖学基础，证明了大鼠视网膜下丘脑投射。摩尔和Eichler 4也报道了SCN损伤后肾上腺皮质酮昼夜节律的丧失。然而，SCN损伤对睡眠-觉醒周期的影响，特别是损伤是否特别影响慢波睡眠或异相睡眠的量，迄今为止还没有被证明。在本文中，将报告双侧SCN病变以及双侧眼球摘除对大鼠睡眠-觉醒周期的影响。
Rats exposed to environmental illumination with the normal day-night cycle exhibit the greater portion of each day's sleep during the light hours 1, 6. Stephan and Zucker 7 demonstrated that bilateral lesions of the suprachiasmatic nucleus (SCN) in rats permanently eliminated circadian rhythm in drinking behavior and locomotor activity which were significantly more frequent during dark hours before the lesions. A possible anatomical basis of this phenomenon demonstrating a retinohypothalamic projection in the rat was described by Moore and Lenn 5. Loss of circadian adrenocorticosterone rhythm after SCN lesions was also reported by Moore and Eichler 4.However, the effects of SCN lesions on the sleep-wakefulness cycle, especially whether the lesions influence specifically the amount of slow-wave sleep or paradoxical sleep, have thus far not been shown. In this communication the effects of bilateral SCN lesions as well as bilateral enucleation on the sleep-wakefulness cycle in rats will be reported.