The surface-mosaic model in host-parasite relationships
The surface-mosaic model in host-parasite relationships
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DOI：
10.1016/j.pt.2004.08.005
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发表时间：
2004-11-01
影响因子：
9.6
通讯作者：
Titus, RG
中科院分区：
文献类型：
--
作者：
Mejia, JS;Moreno, F;Titus, RG
蛋白质吸附到微生物表面的动力学可能在宿主-寄生虫关系中具有重要意义，因为非防御蛋白可能会干扰防御蛋白的结合。在微生物表面上形成的防御和非防御蛋白质的表面镶嵌可以通过由吸附的蛋白质产生的二进制代码（帮助或沉默）激活组织反应程序之一。了解马赛克的形成和进化机制可能有助于确定有毒微生物的逃避机制。这也提供了一个概念框架，以设计新的战略来控制它们引起的传染病。
The dynamics of protein adsorption to a microbial surface could be of significance in host-parasite relationships because non-defense proteins might interfere with the binding of defense proteins. A surface mosaic of defense and non-defense proteins formed on the microbial surface could activate one of the tissue reactivity programs via a binary code (help or silence) generated by the adsorbed proteins. Understanding the mechanisms of the mosaic formation and its evolution might help to identify evasion mechanisms used by virulent microorganisms. This also provides a conceptual framework to design new strategies to control the infectious diseases they cause.