The biphasic behavior of incoherent feed-forward loops in biomolecular regulatory networks
The biphasic behavior of incoherent feed-forward loops in biomolecular regulatory networks
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DOI：
10.1002/bies.20839
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发表时间：
2008-11-01
期刊：
影响因子：
4
通讯作者：
Cho, Kwang-Hyun
中科院分区：
文献类型：
--
作者：
Kim, Dongsan;Kwon, Yung-Keun;Cho, Kwang-Hyun
非相干前馈环(FFL)是生物分子调控网络中最常见的模体之一。有人认为，非连贯的FFL被设计成简单地诱导一种由“快速激活和延迟抑制”形成的瞬时反应。我们发现，各种非相干FFL的动力学可以进一步分为两种类型：依赖于时间的双相响应和依赖于剂量的双相响应。为什么结构相同的非相干FFL扮演着如此不同的动力学角色？通过计算研究，我们证明了这两类非相干有限状态机的动力学特性是相互排斥的。根据进一步的计算结果和实验观察，我们假设非相干FFL已经被优化设计，以实现来自不同细胞环境的不同生物功能。其他支持信息可在文章的在线版本中找到。《生物文集》30：1204-1211,2008。(C)2008年威利期刊公司。
An incoherent feed-forward loop (FFL) is one of the most-frequently observed motifs in biomolecular regulatory networks. It has been thought that the incoherent FFL is designed simply to induce a transient response shaped by a 'fast activation and delayed inhibition'. We find that the dynamics of various incoherent FFLs can be further classified into two types: time-dependent biphasic responses and dose-dependent biphasic responses. Why do the structurally identical incoherent FFLs play such different dynamical roles? Through computational studies, we show that the dynamics of the two types of incoherent FFLs are mutually exclusive. Following from further computational results and experimental observations, we hypothesize that incoherent FFLs have been optimally designed to achieve distinct biological function arising from different cellular contexts. Additional Supporting Information may be found in the online version of the article. BioEssays 30:1204-1211, 2008. (C) 2008 Wiley Periodicals, Inc.