Current understanding of the mechanism and role of ROS in angiotensin II signal transduction.
Current understanding of the mechanism and role of ROS in angiotensin II signal transduction.
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DOI：
10.2174/138920106776597667
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发表时间：
2006-03
影响因子：
2.8
通讯作者：
Hiroyuki Suzuki;G. D. Frank;H. Utsunomiya;S. Higuchi;S. Eguchi
中科院分区：
文献类型：
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作者：
Hiroyuki Suzuki;G. D. Frank;H. Utsunomiya;S. Higuchi;S. Eguchi
活性氧（Reactive oxygen species， ROS）通过多种机制诱导动脉粥样硬化、高血压等心血管疾病。其中一种机制涉及ROS作为细胞内第二信使，导致诱导独特的信号转导。血管紧张素II （AngII）是一种有效的心血管病原体，通过血管NADPH氧化酶刺激ROS的产生。AngII诱导的ROS产生激活下游ROS敏感激酶，这些激酶在介导心血管重构中起关键作用。基因转移/敲除技术的最新进展导致了大量体外和体内研究，这些研究确定了AngII促进心血管重塑的ROS信号转导的潜在成分和机制。在这篇综述中，我们将重点讨论利用现有的分子生物技术阐明AngII诱导ROS产生和功能的信号转导研究。
Reactive oxygen species (ROS) are proposed to induce cardiovascular diseases, such as atherosclerosis and hypertension, through several mechanisms. One such mechanism involves ROS acting as intracellular second messengers, which lead to induction of unique signal transductions. Angiotensin II (AngII), a potent cardiovascular pathogen, stimulates ROS production through vascular NADPH oxidases. The ROS production induced by AngII activates downstream ROS-sensitive kinases that are critical in mediating cardiovascular remodeling. Recent advances in gene transfer/knockout techniques have lead to numerous in vitro and in vivo studies that identify the potential components and mechanisms of ROS signal transduction by AngII which promote cardiovascular remodeling. In this review, we will focus our discussion on the signal transduction research elucidating ROS production and function induced by AngII using currently available molecular biotechnologies.