Cyclic AMP--an intracellular second messenger for interleukin 1.
Cyclic AMP--an intracellular second messenger for interleukin 1.
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环 AMP——白细胞介素 1 的细胞内第二信使。
DOI：
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发表时间：
1988
影响因子：
11.1
通讯作者：
S. Mizel
中科院分区：
文献类型：
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作者：
Fumihiko Shirakawa;Uki YAMASHITAt;Marcio Chedid;S. Mizel
我们证明白细胞介素1（IL-1）是免疫和炎症反应中的一种有效肽介导剂，可以刺激多种IL-1反应细胞靶点中的cAMP合成。我们还表明，cAMP类似物和cAMP诱导剂可以取代IL-1诱导白细胞介素2受体的淋巴细胞，以及在植物血凝素诱导小鼠胸腺细胞增殖。通过使用IL-1和cAMP诱导剂，毛喉素，cAMP的诱导水平和淋巴细胞白细胞介素2受体表达或胸腺细胞增殖的程度之间的直接相关性建立。我们的结果表明，cAMP可能是一个重要的细胞内第二信使IL-1。
We demonstrated that interleukin 1 (IL-1), a potent peptide mediator in immune and inflammatory responses, stimulates the synthesis of cAMP in a variety of IL-1-responsive cell targets. We also showed that cAMP analogs and cAMP-inducing agents can replace IL-1 in the induction of interleukin 2 receptors on lymphocytes as well as in phytohemagglutinin-induced murine thymocyte proliferation. By use of IL-1 and the cAMP-inducer, forskolin, a direct correlation between the induced level of cAMP and the degree of lymphocyte interleukin 2 receptor expression or thymocyte proliferation was established. Our results indicate that cAMP may be an important intracellular second messenger for IL-1.