Efficacy and safety of stem cells transplantation in patients with type 1 diabetes mellitus-a systematic review and meta-analysis.
Efficacy and safety of stem cells transplantation in patients with type 1 diabetes mellitus-a systematic review and meta-analysis.
复制标题
干细胞移植治疗 1 型糖尿病患者的疗效和安全性——系统评价和荟萃分析。
DOI：
10.1507/endocrj.ej20-0050
复制
发表时间：
2020-04
影响因子：
2
通讯作者：
Zhang Mei
中科院分区：
文献类型：
--
作者：
Wu Qian;Zheng Shuai;Qin Yao;Zheng Xuqin;Chen Heng;Yang Tao;Zhang Mei
Stem cells (SCs) therapy is a new promising therapeutic modality for type 1 diabetes (T1DM). We performed a systematic review and meta-analysis to evaluate the efficacy and safety of stem cells transplantation (SCT) in patients with T1DM. We searched five literature databases (MEDLINE, EMBASE, Web of Science, WanFang and CENTRAL) up to 31 October 2019. 29 studies (487 patients with T1DM) were included in our meta-analysis. There was no substantial publication bias. Meta-analysis showed the SCT had significant effect to decrease HbA1c (SMD, 1.40; 95% CI, 0.93 to 1.86; p < 0.00001; I2 = 89%) and to improve C-peptide levels (SMD, -0.62; 95% CI, -1.22 to -0.02; p = 0.04; I2 = 92%) at 1 year follow-up. Subgroup analyses showed the heterogeneity level of the results was high. Significant improvement of metabolic outcomes was observed in the subgroups of mesenchymal stem cells (MSCs) combined with hematopoietic stem cells (HSCs) and HSCs. The older age showed significant association with the efficacy in HSCs subgroup. The higher GADA positive rate before treatment also significantly associated with the decrease of daily insulin requirement. The transient insulin independence rate at last follow-up was 9.6 per 100 person-years (95% CI: 5.8-13.5%). The mean length of insulin independence was 15.6 months (95% CI: 12.3-18.9). The mortality of SCT was 3.4% (95% CI: 2.1-5.5%). Therefore, SCT is an efficacious and safe method for treating patients with T1DM especially in the subgroups of MSCs + HSCs and HSCs. Well designed, double blind and randomized controlled trails with large sample size and long-term follow-up are needed for further evaluation.
登录
查看更多内容
影响因子：
4.3
作者：
Vanikar AV;Dave SD;Thakkar UG;Trivedi HL
通讯作者：
Trivedi HL
影响因子：
16.2
作者：
Haller MJ;Wasserfall CH;McGrail KM;Cintron M;Brusko TM;Wingard JR;Kelly SS;Shuster JJ;Atkinson MA;Schatz DA
通讯作者：
Schatz DA
影响因子：
2
作者：
Ma XR;Tang YL;Xuan M;Chang Z;Wang XY;Liang XH
通讯作者：
Liang XH
DOI：
10.12659/msm.889525
发表时间：
2013-10-14
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Mesples A;Majeed N;Zhang Y;Hu X
通讯作者：
Hu X
DOI：
--
发表时间：
2014
期刊：
China Modern Doctor
影响因子：
--
作者：
Hou Ta
通讯作者：
Hou Ta