Miniaturized Molecularly Imprinted Continuous Polymer Rods
Miniaturized Molecularly Imprinted Continuous Polymer Rods
复制标题
小型化分子压印连续聚合物棒
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
J. Matsui
中科院分区：
文献类型：
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作者：
T. Takeuchi;J. Matsui
在内径为1 mm的PEEK管中制备分子印迹连续聚合物棒。通过原位制备技术;并且已经证明了在这样的介质上的手性分离。填充有基于2-（三氟甲基）丙烯酸和乙二醇二甲基丙烯酸酯的共聚物的（-）-辛可尼定印迹或（+）-辛可宁印迹聚合物棒的小型化柱允许（-）-辛可尼定和（+）-辛可宁的非对映体分离;模板分子比相应的对映体保留更大的程度。增加聚合混合物中环己醇的量降低了所得棒的背压，并且向预聚合混合物中加入悬浮在水中的胶乳珠影响了印迹聚合物棒的选择性和亲和力。柱长可通过切割轻松调节，因此可轻松控制保留行为和分析时间。
Molecularly imprinted continuous polymer rods are prepared inside PEEK tubes of 1 mm i. d. by an in situ preparation technique; and chiral separations on such media have been demonstrated. The miniaturized column filled with (–)-cinchonidine-imprinted or (+)-cinchonine-imprinted polymer rods based on a copolymer of 2-(trifluoromethyl)acrylic acid and ethylene glycol dimethacrylate permitted diastereoseparation of (–)-cinchonidine and (+)-cinchonine; the template molecule is retained to a greater extent than the corresponding antipode. Increasing the amount of cyclohexanol in the polymerization mixture decreased the backpressure of the resultant rod and the addition of latex beads suspended in water to the prepolymerization mixture affected the selectivity and affinity of the imprinted polymer rods. The column length is adjusted easily by cutting, thus allowing easy control of retention behavior and analysis time.