Toll-like receptor signaling in uterine natural killer cells-role in embryonic loss
Toll-like receptor signaling in uterine natural killer cells-role in embryonic loss
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DOI：
10.1016/j.jri.2009.09.004
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发表时间：
2009-12-01
影响因子：
3.4
通讯作者：
Saito, Shigeru
中科院分区：
文献类型：
--
作者：
Lin, Yi;Nakashima, Akitoshi;Saito, Shigeru
胚胎发育是一个复杂的过程，受多种细胞类型和信号通路的调控。本文就NK细胞和调节性T细胞(Treg细胞)在胚胎丢失中的作用作一综述。大约70%的子宫白细胞直到妊娠中期被发现是CD16(-)CD56(明亮)NK细胞。这个NK细胞亚群和Treg细胞一起，已经被证明可以调节胎儿的发育。我们最近在妊娠小鼠子宫中发现了一群NK细胞，具有独特的CD3(-)CD49b(+)CD25(+)Foxp3(+)表型。本文综述了CD3(-)、CD49b(+)、CD25(+)、Foxp3(+)细胞表达IL-10和CD16(-)CD56(Bright)NK细胞表达CXCR4在防止胚胎丢失中的重要作用。此外，还讨论了Toll样受体和CXCR4在NK细胞迁移和功能调节中的作用。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Embryonic development is a complex process that is regulated by many cell types and signaling pathways. This review focuses on the role of NK cells and regulatory T-cells (Treg cells) in embryonic loss. Approximately 70% of uterine leukocytes until the time of mid-gestation are found to be CD16(-)CD56(bright) NK cells. This subset of NK cells, along with Treg cells, has been shown to regulate fetal development. We recently found a population of NK cells in the pregnant mouse uterus with a unique CD3(-)CD49b(+)CD25(+)Foxp3(+) phenotype. This review summarizes the studies indicating critical roles for expression of IL-10 by CD3(-)CD49b(+)CD25(+)Foxp3(+) cells and CXCR4 expression on CD16(-)CD56(bright) NK cells in preventing embryonic loss. In addition, the roles of toll-like receptors (TLRs) and CXCR4 in NK cell migration and functional modulation are discussed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.