Analysis of intrahepatic lymphocyte subsets in a transgenic mouse model of immune-mediated hepatocarcinogenesis.
Analysis of intrahepatic lymphocyte subsets in a transgenic mouse model of immune-mediated hepatocarcinogenesis.
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发表时间：
2006-03
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通讯作者：
Y. Nakamoto;S. Kaneko
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作者：
Y. Nakamoto;S. Kaneko
长期持续的肝细胞损伤增加了慢性病毒性肝炎患者发生肝细胞癌（HCC）的风险。为了支持这一观点，我们开发了一种独特的慢性免疫介导的肝病动物模型，该模型使用HBV转基因小鼠诱导肝细胞癌发生;然而，肝内炎症反应没有得到精确评估。目前的研究表明，在肝脏中检测到B表面抗原（HBsAg）特异性细胞毒性T淋巴细胞（CTL）的频率为0.05%的CD 8 + T淋巴细胞，单核细胞/巨噬细胞随着疾病的发展而显著增加。这些结果表明，少量肝内病毒特异性CTL和募集的单核细胞/巨噬细胞可能有助于慢性肝脏炎症的过程。
Long-term, persistent liver cell injury increases the risk for hepatocellular carcinoma (HCC) development in chronic viral hepatitis. In support of this notion, we have developed a unique animal model of chronic immune-mediated liver disease that induces hepatocellular carcinogenesis using HBV transgenic mice; however, the intrahepatic inflammatory response was not precisely evaluated. The current study demonstrated that hepatitis B surface antigen (HBsAg)-specific cytotoxic T lymphocytes (CTLs) were detected at a frequency of 0.05% of CD8+ T lymphocytes in the liver, and that monocytes/macrophages were remarkably increased as the disease developed. These results suggest that a minimal number of intrahepatic virus-specific CTLs and the recruited monocytes/macrophages may contribute to the process of chronic liver inflammation.