The erythema Q-score, an imaging biomarker for redness in skin inflammation.
The erythema Q-score, an imaging biomarker for redness in skin inflammation.
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红斑Q评分，皮肤炎症发红的成像生物标志物。
DOI：
10.1111/exd.14224
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发表时间：
2021-03
影响因子：
3.6
通讯作者：
Gareau D
中科院分区：
文献类型：
--
作者：
Frew J;Penzi L;Suarez-Farinas M;Garcet S;Brunner PM;Czarnowicki T;Kim J;Bottomley C;Finney R;Cueto I;Fuentes-Duculan J;Ohmatsu H;Lentini T;Yanofsky V;Krueger JG;Guttman-Yassky E;Gareau D
皮肤红斑的医生评级是临床皮肤病学评估以及在许多皮肤病条件的临床试验中的结果测量的量化的中心。然而，在较高菲茨帕特里克皮肤类型的情况下，评估者间的可靠性和变异性问题使得目视红斑评估不可靠。我们开发并验证了一种计算机辅助图像处理算法（EQ评分），可在皮肤科临床环境中可靠地量化红斑（各种皮肤类型）。我们的图像处理算法基于受影响和未受影响皮肤之间的绿色光抑制差异来评估红斑。一组由4名皮肤科医生组成的小组使用4分Likert量表对类似的过敏斑贴试验进行人体评价。在164例阳性斑贴试验反应中比较了算法和皮肤科医生评分。计算组内相关系数和组间相关系数。EQ评分在银屑病独立图像集、最小红斑剂量测试和类固醇诱导的发白图像上进行了验证。红斑量化方法的可靠性产生了算法的类内相关系数为0.84，皮肤科医生的类内相关系数为0.67。组间相关系数为0.85。EQ评分与临床评分具有高度一致性，与临床评分相比具有上级可靠性，避免了在色素沉着情况下低估红斑的缺陷。EQ评分易于访问（http：//lab.rockefeller.edu/krueger/EQscore），用户友好，并且可以允许皮肤科医生更容易和准确地评估皮肤病的严重程度和对治疗性治疗的反应。
Physician rating of cutaneous erythema is central to clinical dermatological assessment as well as quantification of outcome measures in clinical trials in a number of dermatologic conditions. However, issues with inter‐rater reliability and variability in the setting of higher Fitzpatrick skin types make visual erythema assessment unreliable. We developed and validated a computer‐assisted image‐processing algorithm (EQscore) to reliably quantify erythema (across a range of skin types) in the dermatology clinical setting. Our image processing algorithm evaluated erythema based upon green light suppression differentials between affected and unaffected skin. A group of four dermatologists used a 4‐point Likert scale as a human evaluation of similar erythematous patch tests. The algorithm and dermatologist scores were compared across 164 positive patch test reactions. The intra‐class correlation coefficient of groups and the correlation coefficient between groups were calculated. The EQscore was validated on and independent image set of psoriasis, minimal erythema dose testing and steroid‐induced blanching images. The reliability of the erythema quantification method produced an intra‐class correlation coefficient of 0.84 for the algorithm and 0.67 for dermatologists. The correlation coefficient between groups was 0.85. The EQscore demonstrated high agreement with clinical scoring and superior reliability compared with clinical scoring, avoiding the pitfalls of erythema underrating in the setting of pigmentation. The EQscore is easily accessible (http://lab.rockefeller.edu/krueger/EQscore), user‐friendly, and may allow dermatologists to more readily and accurately rate the severity of dermatological conditions and the response to therapeutic treatments.
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影响因子：
1.2
作者：
Heckman, Carolyn J.;Chandler, Rachel;Oslin, David W.
通讯作者：
Oslin, David W.
影响因子：
4.1
作者：
Hubbard, V. G.;Goddard, D. J.;Walker, S. L.
通讯作者：
Walker, S. L.
影响因子：
--
作者：
Zhao CY;Wijayanti A;Doria MC;Harris AG;Jain SV;Legaspi KN;Dlova NC;Law MG;Murrell DF
通讯作者：
Murrell DF
影响因子：
3.6
作者：
Becker, Detlef
通讯作者：
Becker, Detlef
DOI：
10.1016/j.jaip.2015.02.009
发表时间：
2015-05-01
影响因子：
9.4
作者：
Fonacier, Luz;Bernstein, David I.;Wallace, Dana
通讯作者：
Wallace, Dana