Serum albumin and serum globulin after intravenous injection of large amounts of globulin and albumin; a hypothesis about the regulations of the colloid-osmotic pressure of the blood.
Serum albumin and serum globulin after intravenous injection of large amounts of globulin and albumin; a hypothesis about the regulations of the colloid-osmotic pressure of the blood.
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静脉注射大量球蛋白和白蛋白后的血清白蛋白和血清球蛋白；
DOI：
10.1111/j.1699-0463.1945.tb04068.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
M. Bjørneboe
中科院分区：
文献类型：
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作者：
M. Bjørneboe
作者在以前的工作中研究了免疫过程中家兔血清蛋白的变化。通过一种特殊的免疫技术（多价疫苗的强化免疫），证明有可能产生相当程度的高球蛋白血症，球蛋白高达7.86 76。高球蛋白血症与低白蛋白血症相关。这些实验中球蛋白和白蛋白之间的关系从图1中可以明显看出，其中记录了来自这些实验的45份血清，白蛋白是纵坐标，球蛋白是横坐标。(Two来自兔2061和2062的血清被排除在外，因为推测它们含有变性蛋白质。详情请看原文）。应注意，当球蛋白含量增加时，白蛋白含量减少。通过点的直线是在最小平方法之后计算的，并且其具有公式3.2 Alb+。全球= 15.6.这条线周围的点有相当大的分散，但趋势是显而易见的。除球蛋白和白蛋白外，还用Heidelberger & Kabat法测定了血清中抗体蛋白的含量。免疫过程中血清球蛋白的增加可以证明与抗体蛋白相同。在免疫期间，动物中的正常球蛋白（总球蛋白减去抗体球蛋白）保持恒定。为了解释血清白蛋白的降低，提出了一个假设：
In a previous work') the writer has studied the serum proteins in rabbits during immunization. By means of a special immunizing technique (intensive immunization with polyvalent vaccine) it proved possible to produce a considerable degree of hyperglobulinemia, with up to 7.86 76 globulin. This hyperglobulinemia was associated with hypoalbuminemia. The relation between globulin and albumin in these experiments is evident from Fig. 1, where 45 sera from these experiments are recorded so that albumin is the ordinate, globulin the abscissa.(Two sera, from rabbits 2061 and 2062, are left out, as presumably they contained denatured protein. For details, see the original paper.) It will be noticed that the albumin content decreases when the globulin content increases. The straight line through the points is calculated after the smallest squares' method, and it has the formula 3.2 Alb.+ Glob.= 15.6. There is a rather considerable dispersion of the points round the line, but the tendency is plain enough. Besides globulin and albumin in these sera, also the amount of antibody protein was estimated after Heidelberger & Kabat's method?) The increase in serum globulin during the immunization could be demonstrated to be identical with the antibody protein. The normal globulin (total globulin minus antibody globulin) in the animals kept constant during the immunization. For explanation of the decrease in serum albumin the hypothesis was advanced: that the