Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies.
Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies.
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DOI：
10.5049/ebp.2014.12.2.55
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
So HS
中科院分区：
文献类型：
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作者：
Oh GS;Kim HJ;Shen A;Lee SB;Khadka D;Pandit A;So HS
顺铂是治疗各种实体瘤的最广泛使用和高效的药物之一;然而，它对肾脏、耳蜗和神经具有剂量依赖性副作用。肾毒性是最常见和临床上最重要的毒性。大量研究表明，多种机制，包括氧化应激、DNA损伤和炎症反应，与顺铂诱导的肾毒性密切相关。尽管顺铂诱导的肾毒性的建立可以通过利尿剂和患者的预水化来缓解，但顺铂肾毒性的患病率仍然很高，发生在大约三分之一接受顺铂治疗的患者中。因此，必须开发能够改善顺铂肾毒性的治疗方法。本文综述了顺铂肾毒性的机制，以及在不降低其杀肿瘤活性的前提下保护肾脏的新策略。
Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the most well-known and clinically important toxicity. Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory responses, are closely associated with cisplatin-induced nephrotoxicity. Even though the establishment of cisplatin-induced nephrotoxicity can be alleviated by diuretics and pre-hydration of patients, the prevalence of cisplatin nephrotoxicity is still high, occurring in approximately one-third of patients who have undergone cisplatin therapy. Therefore it is imperative to develop treatments that will ameliorate cisplatin-nephrotoxicity. In this review, we discuss the mechanisms of cisplatin-induced renal toxicity and the new strategies for protecting the kidneys from the toxic effects without lowering the tumoricidal activity.