Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer.
Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer.
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DOI：
10.4161/onci.18852
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发表时间：
2012-05-01
期刊：
影响因子：
7.2
通讯作者：
Tartour E
中科院分区：
文献类型：
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作者：
Pere H;Tanchot C;Bayry J;Terme M;Taieb J;Badoual C;Adotevi O;Merillon N;Marcheteau E;Quillien VR;Banissi C;Carpentier A;Sandoval F;Nizard M;Quintin-Colonna F;Kroemer G;Fridman WH;Zitvogel L;Oudard SP;Tartour E
CD4+CD25+Foxp3+调节性T细胞（Treg）已成为抑制抗肿瘤效应T细胞的优势T细胞群。用于Treg耗竭的初始策略（环磷酰胺、抗CD25 mAb......）也靶向活化的T细胞，因为它们共享许多表型标志物。目前，抑制Treg的改良方法旨在阻断其功能或其向淋巴结和肿瘤微环境的迁移。最近发现最初为其他治疗适应症开发的各种药物（抗血管生成分子、酪氨酸激酶抑制剂等）抑制Treg。预计这些方法将快速转化为临床应用，用于与免疫调节剂联合治疗。
CD4+CD25+Foxp3+ regulatory T cells (Treg) have emerged as a dominant T cell population inhibiting anti-tumor effector T cells. Initial strategies used for Treg-depletion (cyclophosphamide, anti-CD25 mAb…) also targeted activated T cells, as they share many phenotypic markers. Current, ameliorated approaches to inhibit Treg aim to either block their function or their migration to lymph nodes and the tumor microenvironment. Various drugs originally developed for other therapeutic indications (anti-angiogenic molecules, tyrosine kinase inhibitors,etc) have recently been discovered to inhibit Treg. These approaches are expected to be rapidly translated to clinical applications for therapeutic use in combination with immunomodulators.
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募集高危险性CD8（+）T细胞的潜在池募集到抗肿瘤免疫反应中。
DOI：
10.1084/jem.20042167
发表时间：
2005-05-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ercolini AM;Ladle BH;Manning EA;Pfannenstiel LW;Armstrong TD;Machiels JP;Bieler JG;Emens LA;Reilly RT;Jaffee EM
通讯作者：
Jaffee EM
影响因子：
11.5
作者：
Badoual, C;Hans, S;Tartour, E
通讯作者：
Tartour, E
影响因子：
3.9
作者：
Bercovici, Nadege;Haicheur, Nacilla;Tartour, Eric
通讯作者：
Tartour, Eric
影响因子：
32.4
作者：
Boissonnas, Alexandre;Scholer-Dahirel, Alix;Amigorena, Sebastian
通讯作者：
Amigorena, Sebastian
影响因子：
5.8
作者：
Banissi, Claire;Ghiringhelli, Francois;Carpentier, Antoine F.
通讯作者：
Carpentier, Antoine F.