Regenerative medicine bioprocessing: Building a conceptual framework based on early studies
Regenerative medicine bioprocessing: Building a conceptual framework based on early studies
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DOI：
10.1089/ten.2006.0177
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发表时间：
2007-02-01
影响因子：
--
通讯作者：
Hoare, Mike
中科院分区：
文献类型：
--
作者：
Mason, Chris;Hoare, Mike
本文回顾了利用人类细胞和工程组织进行再生医学的早期研究，从以实验室为中心的人工程序到自动化制造。然后，它检查了必须生产自体人体材料的独特生物过程，使用同种异体细胞系和源自它们的工程组织所允许的简化程度，以及影响这两种细胞类型的问题。在此基础上，本文提出了决定再生医学生物加工如何取得进展以经济地提供多单位材料的一些因素。
This paper reviews early studies of regenerative medicine using human cells and engineered tissues progressing from a laboratory-centered manual procedure toward automated manufacture. It then examines the distinctive bioprocesses by which autologous human material must be produced, the degree of simplification allowed by use of allogeneic cell lines and engineered tissue derived from them, and issues that affect both cell types. The paper concludes by drawing upon this discussion to suggest some factors that will determine how regenerative medicine bioprocessing can progress to provide many units of material economically.