A signal detection theory analysis of behavioral pattern separation paradigms.
A signal detection theory analysis of behavioral pattern separation paradigms.
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DOI：
10.1101/lm.038141.115
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Courtney SM
中科院分区：
文献类型：
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作者：
Loiotile RE;Courtney SM
行为模式分离（BPS）范式要求参与者区分先前编码的（旧的）刺激与高度相似的（诱惑）和分类不同的（新的）刺激。旧的诱惑歧视，被认为是唯一反映模式分离的海马结构，是典型的坑对传统的新的歧视。然而，BPS范式测量诱饵旧歧视既不一致的研究，也没有这样一种方式，允许准确比较新的旧歧视。因此，我们主张将信号检测理论（SDT）作为一个统一的框架。此外，我们比较了SDT与以前使用的诱饵旧歧视措施，表明其他公式的不准确性可能导致错误的结论。
Behavioral pattern separation (BPS) paradigms ask participants to discriminate previously encoded (old) stimuli from highly similar (lure) and categorically distinct (novel) stimuli. The lure-old discrimination, thought to uniquely reflect pattern separation in the hippocampal formation, is typically pitted against the traditional novel-old discrimination. However, BPS paradigms have measured lure-old discrimination neither consistently across studies nor in such a way that allows for accurate comparison to novel-old discrimination. Therefore, we advocate for signal detection theory (SDT) as a unified framework. Moreover, we compare SDT with previously used measures of lure-old discrimination, indicating how other formulas’ inaccuracies can lead to erroneous conclusions.