Abyssomicin I, a Modified Polycyclic Polyketide from Streptomyces sp. CHI39
Abyssomicin I, a Modified Polycyclic Polyketide from Streptomyces sp. CHI39
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DOI：
10.1021/np100292h
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发表时间：
2010-11-01
影响因子：
5.1
通讯作者：
Trujillo, Martha E.
中科院分区：
文献类型：
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作者：
Igarashi, Yasuhiro;Yu, Linkai;Trujillo, Martha E.
Abyssomicin I (1) 是一种新型改性多环聚酮化合物，是从土壤来源的链霉菌的培养物提取物中分离出来的。通过核磁共振和其他光谱数据的解释阐明了1的结构。通过NOE分析、化学衍生化和改进的Mosher方法的应用，确定了新化合物的立体化学。虽然1对细菌和酵母无活性，但氧化衍生物7对革兰氏阳性菌表现出弱活性。化合物1和7对肿瘤细胞侵袭具有抑制作用，IC50值分别为11和0.21μM。
Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC50 values of 11 and 0.21 mu M, respectively.