Melanosomes on the move: a model to understand organelle dynamics
Melanosomes on the move: a model to understand organelle dynamics
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DOI：
10.1042/bst0391191
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发表时间：
2011-10-01
影响因子：
3.9
通讯作者：
Seabra, Miguel C.
中科院分区：
文献类型：
--
作者：
Hume, Alistair N.;Seabra, Miguel C.
活细胞显微镜的进展揭示了细胞内细胞器异常动态的本质。此外，运动似乎是建立和维持细胞内组织和细胞器和细胞功能的关键。运动受细胞器相关的运动蛋白、驱动蛋白、动力蛋白和肌球蛋白的活性调节，这些蛋白沿着沿着极性MT（微管）和肌动蛋白轨道移动货物。然而，在大多数情况下，移动特定细胞器的马达仍然是神秘的。近年来，色素细胞内的色素颗粒或黑素体为理解马达蛋白与细胞内细胞器相关联并移动细胞内细胞器的分子机制提供了极好的模型。在本文中，我们讨论了最近的发现，揭示了黑素体运输的机制，并强调未来的前景，使用色素细胞在解开一般的分子机制的细胞内运输。
Advances in live-cell microscopy have revealed the extraordinarily dynamic nature of intracellular organelles. Moreover, movement appears to be critical in establishing and maintaining intracellular organization and organellar and cellular function. Motility is regulated by the activity of organelle-associated motor proteins, kinesins, dyneins and myosins, which move cargo along polar MT (microtubule) and actin tracks. However, in most instances, the motors that move specific organelles remain mysterious. Over recent years, pigment granules, or melanosomes, within pigment cells have provided an excellent model for understanding the molecular mechanisms by which motor proteins associate with and move intracellular organelles. In the present paper, we discuss recent discoveries that shed light on the mechanisms of melanosome transport and highlight future prospects for the use of pigment cells in unravelling general molecular mechanisms of intracellular transport.