Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells
Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells
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DOI：
10.1142/s1793545818500189
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发表时间：
2018-07-01
影响因子：
2.5
通讯作者：
Liu, Liwei
中科院分区：
文献类型：
--
作者：
Liu, Yingyi;Hu, Siyi;Liu, Liwei
在本论文中，我们制备了壳聚糖纳米粒与表没食子儿茶素没食子酸酯(EGCG)之间的纳米药物载体体系，应用于乳腺癌细胞抑制。在该药物载体体系中，壳聚糖为载体，EGCG为药物。从抑制率和生物相容性两方面对其进行了系统的表征和全面的评价。我们还做了细胞划痕实验，结果表明壳聚糖-EGCG纳米粒对乳腺癌细胞的生长有抑制作用。抑制率最高可达21.91%。这项工作揭示了纳米颗粒的修饰为特定的生物医学应用铺平了道路。
In this paper, we prepared the nanoparticle drug carrier system between nanoparticles - chitosan and Epigallocatechin-3-O-gallate (EGCG) for breast cancer cell inhibiting application. For this drug carrier system, chitosan acts as a carrier and EGCG as a drug. Which were systematically characterized and thoroughly evaluated in terms of their inhibition rate and biocompatibility. We also did a cell scratch test and the result indicated that the chitosan-EGCG nanoparticles have inhibitory effect on the growth of breast cancer cells. The inhibition rate could reach up to 21.91%. This work revealed that the modification of nanoparticles paved a way for specific biomedical applications.