Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide.
Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide.
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发表时间：
2007-03
影响因子：
3.7
通讯作者：
T. Furuya;Masayuki Hakoda;N. Ichikawa;K. Higami;Y. Nanke;T. Yago;T. Kobashigawa;Katsushi Tokunaga;N. Tsuchiya;N. Kamatani;S. Kotake
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作者：
T. Furuya;Masayuki Hakoda;N. Ichikawa;K. Higami;Y. Nanke;T. Yago;T. Kobashigawa;Katsushi Tokunaga;N. Tsuchiya;N. Kamatani;S. Kotake
目的评价HLA-DRB 1基因型和抗环瓜氨酸肽抗体（抗CCP抗体）在日本类风湿关节炎（RA）患者发生和放射学进展中的作用。方法对110例发病1年内就诊的早期RA患者（女性88例，男性22例）进行抗CCP抗体水平和HLA-DRB 1基因型检测。同时对265名健康对照者进行HLA-DRB 1基因型检测。在66例患者中，使用Larsen方法评价了2年内的放射学进展。结果110例早期RA患者中抗CCP抗体阳性82例（74.5%）。与对照组和无抗CCP抗体的RA患者相比，具有抗CCP抗体的RA患者的HLA-DRB 1 *0405携带者频率显著增加（比值比[OR] 3.4，95%置信区间[95% CI] 2.0-5.7和OR 3.3，95% CI 1.3-8.6）。一个或两个SE等位基因的携带者与抗CCP抗体的产生显著相关（OR分别为2.7，95%CI 1.1-6.7和OR 9.3，95%CI 1.1-78.2）。与对照组和抗CCP抗体阳性RA患者相比，无抗CCP抗体的RA患者HLA-DRB 1 *0901等位基因频率显著增高（OR分别为2.2，95%CI 1.1-4.1和3.0，95%CI 1.4-6.4）。结论在日本RA患者中，HLA-DRB 1 SE等位基因与抗CCP抗体的产生相关，HLA-DRB 1等位基因与早期RA的相关性与白人RA患者不同，取决于抗CCP阳性。
OBJECTIVE To evaluate the role of HLA-DRB1 genotypes and antibodies to cyclic citrullinated peptides (anti-CCP antibodies) in the development and radiographic progression of Japanese patients with rheumatoid arthritis (RA). METHODS One hundred and ten patients with early RA (88 female, 22 male) who visited our clinic within 1 year of symptom onset were examined for anti-CCP antibody levels and HLA-DRB1 genotypes. HLA-DRB1 genotypes were also determined in 265 healthy controls. Radiographic progression over a 2-year interval was evaluated using the Larsen's method in 66 patients. RESULTS Among the 110 patients with early RA, 82 patients (74.5%) were anti-CCP positive. Carrier frequency of HLA-DRB1*0405 was significantly increased in RA patients with anti-CCP antibodies compared with controls and RA patients without anti-CCP antibodies (odds ratio [OR] 3.4, 95% confidence interval [95% CI] 2.0-5.7 and OR 3.3, 95% CI 1.3-8.6, respectively). Carriership of one or two SE alleles was significantly associated with production of anti-CCP antibodies (OR 2.7, 95% CI 1.1-6.7 and OR 9.3, 95% CI 1.1-78.2, respectively). On the other hand, allele frequency of HLA-DRB1*0901 was significantly increased in RA patients without anti-CCP antibodies compared with controls and RA patients with anti-CCP antibodies (OR 2.2, 95% CI 1.1-4.1 and OR 3.0, 95% CI 1.4-6.4, respectively). CONCLUSION In Japanese patients with RA, HLA-DRB1 SE alleles are associated with production of anti-CCP antibodies and HLA-DRB1 alleles appear to be differently associated with early RA depending on anti-CCP positivity as in Caucasian patients with RA.