EPITHELIOID SARCOMA - DIAGNOSIS, PROGNOSTIC INDICATORS, AND TREATMENT
EPITHELIOID SARCOMA - DIAGNOSIS, PROGNOSTIC INDICATORS, AND TREATMENT
复制标题
DOI：
10.1097/00000478-198504000-00001
复制
发表时间：
1985-01-01
影响因子：
5.6
通讯作者：
ENZINGER, FM
中科院分区：
文献类型：
--
作者：
CHASE, DR;ENZINGER, FM
对241例上皮样肉瘤的回顾性分析再次证实了这种肿瘤发生在年轻人四肢远端的倾向。肿瘤通常坚硬无压痛，累及真皮、皮下组织或更深的软组织，特别是筋膜平面、腱膜和腱鞘。202例（84%）的随访数据显示复发率为77%，转移率为45%。最常见的初始转移部位是淋巴结（48%）和肺（25%）。侵袭性更强的病程与肿瘤位于近端或轴向、肿瘤大小和深度增加、出血、核分裂像、坏死或血管浸润有关。当肿瘤发生在较年轻的个体、远端肢体或年龄在10-49岁之间的女性时，观察到更有利的行为。(The最后的观察需要进一步研究类固醇受体。）根治性切除或截肢似乎仍是首选的治疗方法，但对切除部位进行连续性高剂量放射治疗可能具有额外的价值。
A retrospective review of 241 cases of epithelioid sarcoma reaffirmed the propensity of this tumor to occur in the distal extremities of young adults. The tumor was generally firm and nontender and involved the dermis, subcutis or deeper soft tissues, particularly fascial planes, aponeuroses and tendon sheaths. Follow-up data, available in 202 cases (84%), showed a 77% recurrence and a 45% metastatic rate. The most common initial sites of metastases were lymph nodes (48%) and lungs (25%). A more aggressive course was associated with a proximal or axial tumor location, increased size and depth, hemorrhage, mitotic figures, necrosis, or the presence of vascular invasion. More favorable behavior was observed when the tumor arose in younger individuals, in distal extremities, or in females between the ages of 10-49 yr. (The last observation calls for further work with steroid receptors.) Radical excision or amputation still appears to be the initial treatment of choice, though adjunctive high-dose radiotherapy to the excision site may prove to be of additional value.