Cardiac Regeneration: Lessons From Development.
Cardiac Regeneration: Lessons From Development.
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DOI：
10.1161/circresaha.116.309040
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发表时间：
2017-03-17
影响因子：
20.1
通讯作者：
Pu WT
中科院分区：
文献类型：
--
作者：
Galdos FX;Guo Y;Paige SL;VanDusen NJ;Wu SM;Pu WT
先天性心脏病的姑息手术使以前致命的心脏畸形患者得以生存，在大多数情况下，茁壮成长。然而，这些程序经常对心脏施加压力和容量负荷，随着时间的推移，这些慢性负荷可能导致心力衰竭。目前用于初始手术和由失败的姑息治疗引起的慢性心力衰竭的治疗选择部分地受到哺乳动物心脏形成新心肌细胞（CM）的低固有能力的限制。克服心脏再生障碍将改变先天性和后天性心脏病的治疗，同样也将使个性化的体外心脏病模型的开发成为可能。虽然这些目标仍然遥远，但心脏发育的研究正在照亮前进的道路，并提出心脏再生的独特机会，特别是在胎儿和新生儿时期。在这里，我们回顾了心脏发育的主要经验教训，为当前和未来旨在增强心脏再生的研究提供信息。
Palliative surgery for congenital heart disease has allowed patients with previously lethal heart malformations to survive and, in most cases, to thrive. However, these procedures often place pressure and volume loads on the heart, and over time these chronic loads can cause heart failure. Current therapeutic options for initial surgery and chronic heart failure that results from failed palliation are limited, in part, by the mammalian heart’s low inherent capacity to form new cardiomyocytes (CMs). Surmounting the heart regeneration barrier would transform the treatment of congenital, as well as acquired, heart disease, and likewise would enable development of personalized, in vitro cardiac disease models. Although these remain distant goals, studies of heart development are illuminating the path forward and suggest unique opportunities for heart regeneration, particularly in fetal and neonatal periods. Here we review major lessons from heart development that inform current and future studies directed at enhancing cardiac regeneration.