PROLIFERATION AND MIGRATION OF EPITHELIAL CELLS - DURING CORNEAL WOUND REPAIR IN RABBIT AND RAT
PROLIFERATION AND MIGRATION OF EPITHELIAL CELLS - DURING CORNEAL WOUND REPAIR IN RABBIT AND RAT
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DOI：
10.1016/0002-9394(66)90747-1
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发表时间：
1966-01-01
影响因子：
4.2
通讯作者：
HANNA, C
中科院分区：
文献类型：
--
作者：
HANNA, C
在兔和大鼠角膜上造成伤口，并利用胸苷-H3和自显影来估计脱氧核糖核酸（DNA）合成的变化。在愈合过程的早期，上皮的每一层都滑入伤口的弹坑中。在此之后，在距离伤口一定距离的基底上皮细胞中，DNA合成和有丝分裂停止。一天之内，伤口边缘附近的基质细胞开始合成DNA，并持续到伤口愈合。还有一波细胞分裂，向伤口弹坑移动，最后涉及愈合伤口弹坑上方的基底上皮细胞，然后恢复正常。这些变化与皮肤伤口愈合中观察到的变化非常相似。
Corneal wounds were produced in rabbits and rats and the changes in deoxyribonucleic acid (DNA) synthesis were estimated utilizing thymidine-H3 and auto-radiography. Early in the healing process each layer of the epithelium slides into the wound crater. After this, there is a cessation of DNA synthesis and mitosis in the basal epithelial cells reaching some distance from the wound. Within a day, DNA synthesis in stromal cells near the wound edge begins, and this continues until the wound is healed. There is also a wave of cell division that moves toward the wound crater and finally involves the basal epithelial cells above the healed wound crater before returning to normal. These changes closely resemble those seen in healing of skin wounds.