DEHP metabolites in urine of children and DEHP in house dust
DEHP metabolites in urine of children and DEHP in house dust
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DOI：
10.1078/1438-4639-00309
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发表时间：
2004-10-01
影响因子：
6
通讯作者：
Ullrich, D
中科院分区：
文献类型：
--
作者：
Becker, K;Seiwert, M;Ullrich, D
分析了德国儿童环境调查（GerES IV）2001/2002年试点研究的尿液样本中DEHP主要代谢物MEHP（邻苯二甲酸单（2-乙基己基）酯）和两种DEHP次要代谢物5 OH-MEHP（邻苯二甲酸2-乙基-5-羟基-己基酯）和5 oxo-MEHP（邻苯二甲酸2-乙基-5-氧代-己基酯）的浓度。从254名3至14岁的儿童身上采集了尿液样本。此外，还分析了室内灰尘样本中的DEHP。这些样本是在儿童家中用吸尘器收集的。尿液中MEHP的几何平均值（GM）为7.9 mug/l，次级代谢物5 OH-MEHP和5 oxo-MEHP的GM分别为52.1 mug/l和39.9 mug/l。5 OH-MEHP和5 oxo-MEHP浓度高度相关（r=0.98）。5 OH-MEHP和5 oxo-MEHP与MEHP的相关性也很高（r=0.72和r=0.70）。5 OH-MEHP和5 oxo-MEHP的浓度分别是MEHP浓度的8.0倍和6.2倍。5 OH-MEHP/5 oxo-MEHP和5 oxo-MEHP/MEHP比值随年龄增长而降低，男孩尿液中DEHP的三种代谢物浓度均高于女孩。13 - 14岁儿童尿液中次级代谢物的平均浓度最低。室内灰尘分析显示所有样本均受到DEHP污染。GM为508 mg/kg粉尘。尿液中DEHP代谢物的水平与室内灰尘中DEHP的水平之间没有相关性。
Urine samples from the 2001/2002 pilot study for the German Environmental Survey on children (GerES IV) were analysed for concentrations of the primary DEHP metabolite MEHP (mono(2-ethylhexyl)phthalate) and two secondary DEHP metabolites 5OH-MEHP (2-ethyl-5-hydroxy-hexylphthalate) and 5oxo-MEHP (2-ethyl-5-oxo-hexylphthalate). Urine samples had been taken from 254 children aged 3 to 14. In addition, DEHP was analysed in house dust samples. These samples had been collected with vacuum cleaners in the homes of the children.The geometric mean (GM) was 7.9 mug/l for MEHP in urine, and the GMs for the secondary metabolites 5OH-MEHP and 5oxo-MEHP were 52.1 mug/l and 39.9 mug/l. 5OH-MEHP and 5oxo-MEHP concentrations were highly correlated (r=0.98). The correlations of 5OH-MEHP and 5oxo-MEHP with MEHP were also high (r=0.72 and r=0.70). The concentrations of 5OH-MEHP and 5oxo-MEHP were 8.0-fold and 6.2-fold higher than the concentrarions of MEHP. The ratios 5OH-MEHP/5oxo-MEHP and 5oxo-MEHP/MEHP decreased with increasing age.Boys showed higher concentrations than girls for all three metabolites of DEHP in urine. Children aged 13 - 14 had the lowest mean concentrations of the secondary metabolites in urine. The house dust analyses revealed DEHP contamination of all samples. The GM was 508 mg/kg dust. No correlation could be observed between the levels of any of the urinary DEHP metabolites and those of DEHP in house dust.