Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae
Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae
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DOI：
10.1099/vir.0.80982-0
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发表时间：
2005-06-01
影响因子：
3.8
通讯作者：
Hedrick, RP
中科院分区：
文献类型：
--
作者：
Waltzek, TB;Kelley, GO;Hedrick, RP
分析了四个完整基因的序列，以确定锦鲤疱疹病毒（KHV）与疱疹病毒科中的三种鱼类病毒的相关性：鲤鱼疱疹病毒（Cyprinid疱疹病毒1，CyHV-1）、金鱼造血坏死疱疹病毒（Cyprinid疱疹病毒2，CyHV-2）和斑点叉尾鮰病毒（Ictalurid疱疹病毒1， IHV-1）。这些基因预计会编码解旋酶、衣壳间三链体蛋白、DNA 聚合酶和主要衣壳蛋白。结果表明，KHV 与 CyHV-1 和 CyHV-2 密切相关，而这三种鲤科病毒与 IcHV-1 相关性较远，但相关性较远。来自四个不同地理区域的 12 株 KHV 分离株产生了相同的 DNA 聚合酶基因区域序列。这些发现以及之前发表的形态学和生物学数据表明，KHV 应加入疱疹病毒科相关低等脊椎动物病毒的行列，正式名称为鲤科疱疹病毒 3 (CyHV-3)。
The sequences of four complete genes were analysed in order to determine the relatedness of koi herpesvirus (KHV) to three fish viruses in the family Herpesviridae: carp pox herpesvirus (Cyprinid herpesvirus 1, CyHV-1), haematopoietic necrosis herpesvirus of goldfish (Cyprinid herpesvirus 2, CyHV-2) and channel catfish virus (Ictalurid herpesvirus 1, IcHV-1). The genes were predicted to encode a helicase, an intercapsomeric triplex protein, the DNA polymerase and the major capsid protein. The results showed that KHV is related closely to CyHV-1 and CyHV-2, and that the three cyprinid viruses are related, albeit more distantly, to IcHV-1. Twelve KHV isolates from four diverse geographical areas yielded identical sequences for a region of the DNA polymerase gene. These findings, with previously published morphological and biological data, indicate that KHV should join the group of related lower-vertebrate viruses in the family Herpesviridae under the formal designation Cyprinid herpesvirus 3 (CyHV-3).