EFFICACY OF PROGESTERONE SUPPORT FOR PREGNANCY IN WOMEN WITH RECURRENT MISCARRIAGE - A META-ANALYSIS OF CONTROLLED TRIALS
EFFICACY OF PROGESTERONE SUPPORT FOR PREGNANCY IN WOMEN WITH RECURRENT MISCARRIAGE - A META-ANALYSIS OF CONTROLLED TRIALS
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DOI：
10.1111/j.1471-0528.1989.tb02386.x
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发表时间：
1989-03-01
期刊：
影响因子：
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通讯作者：
DAYA, S
中科院分区：
文献类型：
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作者：
DAYA, S
孕激素似乎是必要的，以支持早期妊娠，并已用于此目的几十年。它的潜在作用，在妇女反复流产由于黄体功能不全已提出，但其疗效尚未得到证实。三项针对复发性流产女性进行的黄体酮治疗对照试验显示，治疗组持续20周以上的怀孕率略有增加，但统计学上不显着。这些研究都没有足够的统计功效来检测结果的临床显著改善，但是使用荟萃分析的原则汇总这些研究的结果可以计算治疗的总体效果。妊娠期至少达到20周的比值比为3.09（95% CI 1.28至7.42），这表明有证据支持孕早期给予孕酮对复发性流产女性有用的建议。虽然，在孕激素是用这种方式，其疗效在妇女反复流产。虽然，在以这种方式使用孕酮之前，其对因黄体功能不全而复发性流产的女性的疗效必须根据本荟萃分析的结果进行前瞻性双盲随机对照试验。
Progesterone appears to be necessary to support an early pregnancy, and has been used for this purpose for several decades. Its potential role in women with recurrent miscarriage due to luteal phase deficiency has been suggested, but its efficacy has not yet been demonstrated. Three controlled trials of progesterone treatment in women with recurrent miscarriage have shown small, but not statistically significant, increases in the rates of pregnancies that continue beyond 20 weeks in the treated groups. None of these studies had sufficient statistical power to detect a clinically significant improvement in outcome but pooling the results of these studies using the principles of meta-analysis has allowed an overall effect of treatment to be calculated. The resulting odds ratio for pregnancies reaching at least 20 weeks gestation was 3.09 (95% CI 1.28 to 7.42) which indicates that there is evidence to support the suggestion that progesterone given in early pregnancy is useful in women with recurrent miscarriage. Although, before progesterone is used in this way its efficacy in women with recurrent miscarriage. Although, before progesterone is used in this way its efficacy in women with recurrent miscarriage due to luteal phase deficiency must be assessed in prospective double-blind randomized controlled trials mounted in the light of the results of this meta-analysis.