A New Bioactive Glass/Collagen Hybrid Composite for Applications in Dentistry
A New Bioactive Glass/Collagen Hybrid Composite for Applications in Dentistry
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DOI：
10.3390/ma12132079
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发表时间：
2019-07-01
期刊：
影响因子：
3.4
通讯作者：
Cannillo, Valeria
中科院分区：
文献类型：
--
作者：
Bellucci, Devis;Salvatori, Roberta;Cannillo, Valeria
生物活性玻璃（BG）目前凭借其骨粘合能力而广泛应用于医疗和牙科应用。将 BG 掺入胶原蛋白基质中可将这些材料的再生潜力与胶原蛋白的特定生物优势结合起来。然而，文献报道的大多数胶原蛋白/BG复合材料都是支架，缺乏可成型的腻子或可注射系统。在此，将含有锶和镁的创新 BG 颗粒与胶原蛋白和 PEG 混合，以获得适合牙科应用的油灰 (BGMS/C)。为了进行比较，使用BG中的金标准45S5 Bioglass((R))颗粒来制备45S5/胶原蛋白腻子。两种复合材料均针对小鼠成纤维细胞进行了体外评估。这些材料表现出优异的生物相容性，使其在牙科和重建手术中的潜在应用很有趣。此外，BGMS/C 似乎可以刺激细胞增殖。
Bioactive glasses (BGs) are currently employed in a wide range of medical and dentistry applications by virtue of their bone-bonding ability. The incorporation of BGs into a collagen matrix may be used to combine the regenerative potential of these materials with the specific biological advantages of collagen. However, most of the collagen/BG composites reported in the literature are scaffolds and there is a lack of moldable putties or injectable systems. Here, granules of an innovative BG containing strontium and magnesium were mixed with collagen and PEG to obtain a putty (BGMS/C) suitable for dental applications. For the sake of comparison, granules of 45S5 Bioglass((R)), the gold standard among BGs, were used to prepare a 45S5/collagen putty. Both the composites were evaluated in vitro with respect to murine fibroblasts. The materials showed an excellent biocompatibility, making them interesting for possible applications in dentistry and reconstructive surgery. Moreover, BGMS/C seems to stimulate cell proliferation.