Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.
Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.
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DOI：
10.1042/bst20160169
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发表时间：
2017-06-15
影响因子：
3.9
通讯作者：
Brautigan DL
中科院分区：
文献类型：
--
作者：
Ziembik MA;Bender TP;Larner JM;Brautigan DL
蛋白磷酸酶-6 （PP6）是参与细胞内信号转导的丝氨酸/苏氨酸磷酸酶PPP家族的一员。PP6在所有真核生物中都是保守的，模式生物的遗传学表明它相对于其他PPP磷酸酶具有非冗余功能。PP6与保守的SAPS亚基相关，并且在脊椎动物物种中与Ankrd亚基形成异源三聚体。多项研究表明PP6在核因子κ b信号传导的不同步骤中发挥负调控作用。PP6催化亚基和PPP6R1亚基在造血细胞和淋巴组织中的表达尤其高。最近有条件地敲除PP6c或PP6R1 （SAPS1）基因的研究已经揭示了对淋巴细胞发育和信号传导的独特影响。
Protein phosphatase-6 (PP6) is a member of the PPP family of Ser/Thr phosphatases involved in intracellular signaling. PP6 is conserved among all eukaryotes, and genetics in model organisms indicates it has non-redundant functions relative to other PPP phosphatases. PP6 functions in association with conserved SAPS subunits and, in vertebrate species, forms heterotrimers with Ankrd subunits. Multiple studies have demonstrated how PP6 exerts negative control at different steps of nuclear factor kappaB signaling. Expression of PP6 catalytic subunit and the PPP6R1 subunit is especially high in hematopoietic cells and lymphoid tissues. Recent efforts at conditionally knocking out genes for PP6c or PP6R1 (SAPS1) have revealed distinctive effects on development of and signaling in lymphocytes.