Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core
Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core
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DOI：
10.1002/pros.20394
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发表时间：
2006-05-15
期刊：
影响因子：
2.8
通讯作者：
Kohri, K
中科院分区：
文献类型：
--
作者：
Kawai, N;Ito, A;Kohri, K
背景。磁铁矿阳离子脂质体 (MCL) 可用于诱导体温过高，因为它们在交变磁场 (AMF) 中产生热量。本研究旨在开发更实用的MCL热疗方法，检查MCL诱导的热疗对人前列腺癌体内的影响。材料和方法。使用了新开发的 AMF 发电机，该发电机采用了带有铁氧体磁芯 (FC) 的螺线管。将人前列腺癌细胞（PC-3和LNCap）皮下注射到裸鼠体内。将MCL注射到肿瘤结节中，并将小鼠以24小时的间隔暴露于AMF中3次（重复热疗；RH），直到观察到肿瘤完全消退。 结果。新开发的装置产生的AMF照射可以充分提高肿瘤组织的温度。频繁的 RH 导致所有裸鼠的肿瘤完全消退。结论。使用 MCL 的 RH 可能是未来治疗激素难治性人类前列腺癌的一种有前途的新疗法。
BACKGROUND. Magnetite cationic liposomes (MCLs) can be used to induce hyperthermia because they generate heat in an alternating magnetic field (AMF). This study aimed at developing more practical method for MCL hyperthermia examining the effect of MCL-induced hyperthermia on human prostate cancer in vivo.MATERIALS AND METHODS. A newly developed AMF generator incorporating a solenoid with a ferrite core (FC) was used. Human prostate cancer cells (PC-3 and LNCap) were injected subcutaneously into nude mice. MCLs were injected into tumor nodule and the mice were exposed into AMF three times at 24-hr intervals (repeated hyperthermia; RH) until complete tumor regression was observed.RESULTS. Irradiation with an AMF generated by newly developed device can adequately increase the temperature of tumor tissue. Frequent RH resulted in complete tumor regression in all nude mice.CONCLUSION. RH using MCLs may be a promising new therapy for hormone-refractory human prostate cancer in the future.