The evolutionary rate of a protein is influenced by features of the interacting partners
The evolutionary rate of a protein is influenced by features of the interacting partners
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DOI：
10.1093/molbev/msj090
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发表时间：
2006-04-01
影响因子：
10.7
通讯作者：
Gojobori, T
中科院分区：
文献类型：
--
作者：
Makino, T;Gojobori, T
蛋白质的进化速率被认为是受蛋白质-蛋白质相互作用（PPI）特征的影响。然而，决定进化速度的相互作用的最重要特征却知之甚少。在这里，我们考虑了酿酒酵母中ppi的四种类型。我们考虑的性质是蛋白质与具有相同功能或不同功能的蛋白质（DF）相互作用的程度，以及这些相互作用涉及PPI网络中密集部分或稀疏部分（SP）连接的程度。我们的发现是，与DF-SP相互作用的蛋白质在所有蛋白质中进化速度最慢。
Rates of protein evolution are thought to be influenced by features of protein-protein interaction (PPI). However, the most important features of interaction for determining the evolutionary rate are poorly understood. Here, we consider four categories for PPIs in Saccharomyces cerevisiae. Properties we consider are the extent to which proteins interact with proteins of the same function or different function (DF) and the extent to which these interactions involve connections in the dense part or sparse part (SP) of a PPI network. Our findings are that proteins with DF-SP interactions evolve at the slowest rate of all the proteins examined.