Adjusting retinol-binding protein concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project
Adjusting retinol-binding protein concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project
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DOI：
10.3945/ajcn.116.142166
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发表时间：
2017-07-01
影响因子：
7.1
通讯作者：
Northrop-Clewes, Christine A.
中科院分区：
文献类型：
--
作者：
Larson, Leila M.;Namaste, Sorrel M. L.;Northrop-Clewes, Christine A.
背景：准确估计维生素A缺乏症（VAD）的患病率对于计划和实施干预措施非常重要。视黄醇结合蛋白（RBP）经常用于人口调查，以衡量维生素A的状态，但它的解释是具有挑战性的设置，炎症是常见的，因为RBP浓度下降，在急性期response.Objectives：我们的目的是评估RBP浓度和炎症和疟疾在学龄前儿童（PSC）之间的关系。（年龄范围：6-59个月）和育龄妇女（WRA）（年龄范围：15-49岁），并研究调整算法来解释这些影响。设计：PSC 8次调查的横截面数据（n = 8803）和4次WRA调查（n = 4191）来自反映贫血炎症和营养决定因素的生物标志物（BRINDA）项目进行了单独分析，并结合使用荟萃分析。探索了几种方法来调整炎症和疟疾背景下PSC中的RBP浓度，如下：1）排除C反应蛋白（CRP）浓度> 5 mg/L或α-1-酸性糖蛋白（AGP）浓度>1 g/L的受试者，2）应用算术校正因子，3）使用回归校正方法。调整对VAD估计患病率的影响（定义为，
Background: The accurate estimation of the prevalence of vitamin A deficiency (VAD) is important in planning and implementing interventions. Retinol-binding protein (RBP) is often used in population surveys to measure vitamin A status, but its interpretation is challenging in settings where inflammation is common because RBP concentrations decrease during the acute-phase response.Objectives: We aimed to assess the relation between RBP concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and to investigate adjustment algorithms to account for these effects.Design: Cross-sectional data from 8 surveys for PSC (n = 8803) and 4 surveys for WRA (n = 4191) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed individually and combined with the use of a meta-analysis. Several approaches were explored to adjust RBP concentrations in PSC in inflammation and malaria settings as follows: 1) the exclusion of subjects with C-reactive protein (CRP) concentrations.5 mg/L or alpha-1-acid glycoprotein (AGP) concentrations >1 g/L, 2) the application of arithmetic correction factors, and 3) the use of a regression correction approach. The impact of adjustment on the estimated prevalence of VAD (defined as,