Is Lactobacillus GG helpful in children with Crohn's disease?: Results of a preliminary, open-label study
Is Lactobacillus GG helpful in children with Crohn's disease?: Results of a preliminary, open-label study
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DOI：
10.1097/00005176-200010000-00024
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发表时间：
2000-10-01
影响因子：
2.9
通讯作者：
Guandalini, S
中科院分区：
文献类型：
--
作者：
Gupta, P;Andrew, H;Guandalini, S
背景：乳杆菌GG是一种安全的益生菌，已知可在人体肠道内短暂定植。已发现其可用于治疗以增加的肠道通透性为特征的几种胃肠道病症。在目前的研究中，乳酸杆菌GG的疗效进行了调查，在儿童克罗恩病。方法：在这个开放标签的试点评估视为一个必要的初步步骤，可能随后的随机安慰剂对照试验，4名儿童轻度至中度活动性克罗恩病给予乳酸杆菌GG（10（10）菌落形成单位[CFU]）肠溶片剂，每天两次，为期6个月。通过双糖渗透性试验测量肠渗透性的变化。临床活动测定通过测量小儿克罗恩病活动index.Results：有一个显着的改善，在临床活动1周后开始乳酸菌GG，这是持续在整个研究期间。第4周时，儿童克罗恩病活动指数评分中位数比基线低73%。肠道通透性改善在一个几乎平行的Fashion.Conclusions：在这个试点研究的结果表明，乳酸杆菌GG可能会改善肠道屏障功能和临床状态的儿童轻度至中度活跃，稳定的克罗恩病。随机，双盲，安慰剂对照试验是必要的，以最终评估乳酸杆菌GG在克罗恩病的疗效。
Background: Lactobacillus GG is a safe probiotic bacterium known to transiently colonize the human intestine. It has been found to be useful in treatment of several gastrointestinal conditions characterized by increased gut permeability. In the current study, the efficacy of Lactobacillus GG was investigated in children with Crohn's disease.Methods: In this open-label pilot evaluation viewed as a necessary preliminary step for a possible subsequent randomized placebo-controlled trial, four children with mildly to moderately active Crohn's disease were given Lactobacillus GG (10(10) colony-forming units [CFU]) in enterocoated tablets twice a day for 6 months. Changes in intestinal permeability were measured by a double sugar permeability test. Clinical activity was determined by measuring the pediatric Crohn's disease activity index.Results: There was a significant improvement in clinical activity 1 week after starting Lactobacillus GG, which was sustained throughout the study period. Median pediatric Crohn's disease activity index scores at 4 weeks were 73% lower than baseline. Intestinal permeability improved in an almost parallel Fashion.Conclusions: Findings in this pilot study show that Lactobacillus GG may improve gut barrier function and clinical status in children with mildly to moderately active, stable Crohn's disease. Randomized, double-blind, placebo-controlled trials are warranted for a final assessment of the efficacy of Lactobacillus GG in Crohn's disease.