An analysis of dietary fiber and fecal fiber components including pH in rural Africans with colorectal cancer.
An analysis of dietary fiber and fecal fiber components including pH in rural Africans with colorectal cancer.
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DOI：
10.5217/ir.2018.16.1.99
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发表时间：
2018-01
影响因子：
4.9
通讯作者：
Adoke KU
中科院分区：
文献类型：
--
作者：
Faruk M;Ibrahim S;Adamu A;Rafindadi AH;Ukwenya Y;Iliyasu Y;Adamu A;Aminu SM;Shehu MS;Ameh DA;Mohammed A;Ahmed SA;Idoko J;Ntekim A;Suleiman AM;Shah KZ;Adoke KU
结直肠癌（CRC）现在是一个主要的公共卫生问题，在非洲农村地区的发病率和死亡率很高，尽管挥之不去的膳食纤维丰富的食品消费。研究表明，增加膳食纤维的摄入量有助于降低粪便pH值，也会影响肠道微生物群的活性，这与CRC的风险降低有关。然而，非洲人明显的高膳食纤维消费是否不再能预防CRC风险尚不清楚。这项研究评估了CRC患者的膳食纤维摄入量，粪便纤维成分和pH值水平。本研究招募了35名受试者（CRC=21，对照=14），平均年龄45岁。采用截短的食物频率问卷和改良的Goering和货车索斯特程序。我们发现，所有受试者都食用了各种富含膳食纤维的食品。对照组膳食纤维摄入量略高于结直肠癌患者。结直肠癌患者粪便中中性洗涤纤维、酸性洗涤纤维、半纤维素、纤维素和木质素的平均含量与对照组相比有显著性差异（P<0.05）。CRC患者的粪便pH值显着高于匹配的明显健康对照组（P=0.017）。两组之间粪便纤维成分和粪便pH值水平的差异可能与非洲农村的CRC发病率和死亡率有关。迫切需要更多的假设驱动的研究，并提供足够的资金，以积累富含膳食纤维的食品对非洲农村结直肠癌的预防作用。
Colorectal cancer (CRC) is now a major public health problem with heavy morbidity and mortality in rural Africans despite the lingering dietary fiber-rich foodstuffs consumption. Studies have shown that increased intake of dietary fiber which contribute to low fecal pH and also influences the activity of intestinal microbiota, is associated with a lowered risk for CRC. However, whether or not the apparent high dietary fiber consumption by Africans do not longer protects against CRC risk is unknown. This study evaluated dietary fiber intake, fecal fiber components and pH levels in CRC patients. Thirty-five subjects (CRC=21, control=14), mean age 45 years were recruited for the study. A truncated food frequency questionnaire and modified Goering and Van Soest procedures were used. We found that all subjects consumed variety of dietary fiber-rich foodstuffs. There is slight preponderance in consumption of dietary fiber by the control group than the CRC patients. We also found a significant difference in the mean fecal neutral detergent fiber, acid detergent fiber, hemicellulose, cellulose and lignin contents from the CRC patients compared to the controls (P<0.05). The CRC patients had significantly more fecal pH level than the matched apparently healthy controls (P=0.017). The identified differences in the fecal fiber components and stool pH levels between the 2 groups may relate to CRC incidence and mortality in rural Africans. There is crucial need for more hypothesis-driven research with adequate funding on the cumulative preventive role of dietary fiber-rich foodstuffs against colorectal cancer in rural Africans “today.”