Selective amnesic effects of oxytocin on human memory
Selective amnesic effects of oxytocin on human memory
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DOI：
10.1016/j.physbeh.2004.07.020
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发表时间：
2004-10-30
影响因子：
2.9
通讯作者：
Hellhammer, DH
中科院分区：
文献类型：
--
作者：
Heinrichs, M;Meinlschmidt, G;Hellhammer, DH
神经肽催产素是哺乳动物分娩和哺乳所必需的。最近的动物研究表明，催产素也涉及行为的中枢神经控制，包括学习和记忆。然而，关于催产素对人类记忆的影响，几乎没有调查。本研究的目的是探讨单剂量鼻内催产素对人类内隐和外显记忆的影响。在一项安慰剂对照的双盲研究中，38名健康男性被随机分配到接受鼻内催产素（24 IU）或安慰剂50分钟前的研究阶段（附带学习）。使用三种不同的记忆测试来测量记忆：内隐感知测试（词干补全）、内隐概念测试（类别线索语义关联）和外显测试（线索回忆）。由于催产素的生殖生物学作用和足够的环境条件的影响，从动物研究中已知的催产素的行为效应的刺激，我们使用的语义词刺激与生殖相关的与中性的意义。与安慰剂治疗相比，催产素显着损害回忆表现，无论在线索回忆测试中单词的含义。在内隐概念测验中，与安慰剂相比，催产素只显著影响了与生殖相关意义相关的目标词的整体生成，而对中性词的生成无显著影响。这些发现与动物研究的数据一致，表明中枢催产素选择性地影响记忆表现，这取决于所使用的记忆测试的类型，更重要的是，刺激的心理生物学相关性。(C)2004年爱思唯尔公司All rights reserved.
The neuropeptide oxytocin is essential for mammalian parturition and lactation. Recent animal studies suggest that oxytocin is also implicated in the central nervous control of behavior including learning and memory. There has been little investigation, however, of the impact of oxytocin on human memory. The purpose of this study was to investigate the effect of a single dose of intranasal oxytocin on implicit and explicit memory in humans. In a placebo-controlled, double-blind study, 38 healthy men were randomly assigned to receive intranasal oxytocin (24 IU) or placebo 50 min before the study phase (incidental learning). Memory was measured using three different memory tests: an implicit perceptual test (word stem completion), an implicit conceptual test (category-cued semantic association), and an explicit test (cued recall). Due to the reproductive-biological role of oxytocin and the impact of adequate environmental conditions for the stimulation of behavioral effects of oxytocin known from animal research, we used semantic word stimuli with reproduction-related vs. neutral meaning. Oxytocin significantly impaired recall performance as compared with placebo treatment irrespective of the meaning of words in the cued recall test. In the implicit conceptual test, characterized by a deepened information processing, compared with placebo, oxytocin significantly impaired only the overall generation of associated target words with reproduction relevant meaning, whereas no significant difference between oxytocin and placebo was obtained for neutral words. These findings concur with data from animal research suggesting that central oxytocin selectively influences memory performance depending on the kind of memory test used and, more importantly, the psychobiological relevance of stimuli. (C) 2004 Elsevier Inc. All rights reserved.