Deranged expression of the E-cadherin/β-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas
Deranged expression of the E-cadherin/β-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas
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DOI：
10.1034/j.1600-0714.2002.00147.x
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发表时间：
2002-09-01
影响因子：
3.3
通讯作者：
Piffkó, J
中科院分区：
文献类型：
--
作者：
Bánkfalvi, A;Krassort, M;Piffkó, J
背景资料：E-cadherin/beta-catenin的异常表达和功能E-cad/β-cat复合物和表皮生长因子受体（EGFR）参与了肿瘤的发生和发展。为了评估这些分子在口腔癌中的作用，我们研究了75例原发性口腔鳞状细胞癌（OSCC），结果：3种分子均在正常上皮的基底/副基底层表达，而在异型增生中EGFR表达显著增加，E-cad/β-cat表达不均匀。在OSCC中，EGFR的过度表达与肿瘤分级较低和预后不良显著相关，E-cad的丢失是生存期缩短的重要标志物，β-cat染色减少是淋巴结转移的预测标志物。结论：口腔癌中细胞间粘附分子和EGFR的表达/功能存在紊乱，具有重大的临床影响。E-cad和β-cat似乎抑制EGFR以促进OSCC的进展。
Background: Deranged expression and function of the E-cadherin/beta-catenin (E-cad/beta-cat) complex and the epidermal growth factor receptor (EGFR) have been implicated in the development and progression of carcinomas.Methods: To estimate the role of these molecules in oral cancer, we investigated 75 primary oral squamous cell carcinomas (OSCCs) with adjacent normal and/or dysplastic mucosa, 30 paired metastases and 12 recurrences by immunohistochemistry.Results: All three molecules were constitutionally expressed in the basal/parabasal layers of tumour adjacent 'normal' epithelium, in contrast to a significant increase of EGFR and heterogeneous expression of E-cad/beta-cat in dysplasia. In OSCCs, overexpression of EGFR correlated significantly with lower tumour grade and poor prognosis, loss of E-cad was a significant marker for shortened survival, reduced beta-cat staining was a predictive marker for lymph node metastasis.Conclusions: There is a perturbance in intercellular adhesion molecules and EGFR expression/function in oral cancer with major clinical impact. E-cad and beta-cat seem to inhibit EGFR to enhance the progression of OSCCs.