Response to Comment on Itoh et al. Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study. Diabetes Care 2018;41:1275–1284
Response to Comment on Itoh et al. Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study. Diabetes Care 2018;41:1275–1284
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对 Itoh 等人对日本高胆固醇血症和糖尿病视网膜病变患者进行强化靶向治疗的评论的回应：2018 年随机研究报告；41：1275–1284
DOI：
10.2337/dci18-0028
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发表时间：
2018
期刊：
影响因子：
16.2
通讯作者：
I. Komuro
中科院分区：
文献类型：
--
作者：
H. Itoh;K. Ueshima;I. Komuro
我们感谢Donzelli等人（1）对我们文章（2）的关注。EMPATHY研究（2）的报告显示，强化组和标准组在主要终点方面没有显著差异，但在脑事件（次要终点之一）方面差异显著。我们的研究没有对次要终点的多重性进行调整。因此，我们同意信函作者（1）的观点，即这些结果没有提供确凿证据表明积极降低低密度脂蛋白胆固醇（LDL - C）的治疗可预防脑事件。这就是为什么我们将对脑事件的研究确定为探索性分析。
我们的研究特别关注他汀类药物对动脉粥样硬化事件影响的评估。因此，我们设定了中风（脑梗死、脑出血、蛛网膜下腔出血）这一次要终点，并在此背景下评估数据。我们相信我们的研究结果支持先前的研究（3），即他汀类药物并不……
We thank Donzelli et al. (1) for their interest in our article (2). The report of the EMPATHY study (2) showed no significant difference between the intensive group and the standard group for the primary end point, but the difference was significant for cerebral events, which was one of the secondary end points. Our study did not adjust for multiplicity of secondary end points. We thus agree with the authors of the letter (1) that these results do not provide substantial evidence that aggressive LDL cholesterol (LDL-C)–lowering therapy prevents cerebral events. This is why we identified our investigation of cerebral events as an exploratory analysis.
Our study focused particularly on the assessment of effects of stains on atherosclerotic events. Thus, we established the secondary end point of stroke (cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage) and assessed the data within that context. We believe that our findings support those of previous studies (3) that statins do not …
影响因子：
3.3
作者：
Matsuzaki, M;Kita, T;Itakura, H
通讯作者：
Itakura, H