THE PRODUCTION OF CYTOKINES BY POLYMORPHONUCLEAR NEUTROPHILS
THE PRODUCTION OF CYTOKINES BY POLYMORPHONUCLEAR NEUTROPHILS
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DOI：
10.1016/0167-5699(95)80066-2
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发表时间：
1995-01-01
期刊：
影响因子：
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通讯作者：
CASSATELLA, MA
中科院分区：
文献类型：
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作者：
CASSATELLA, MA
细胞因子协调复杂的细胞相互作用网络，调节自然和免疫抵抗的效应细胞功能。虽然T细胞、自然杀伤(NK)细胞和单核/巨噬细胞是细胞因子的主要产生者，但近几年的大量报道表明，多形核中性粒细胞(PMN)也具有合成和释放免疫调节细胞因子的能力。在这里，Marco Cassatella 描述了 PMN 调节细胞因子产生的新方面，强调了 PMN 在细胞因子串扰中的参与。
Cytokines orchestrate the complex network of cellular interactions that regulate effector cell functions of natural and immune resistance. Although T cells, natural Killer (NK) cells and monocytes/macrophages are the main producers of cytokines, a number of reports in the last few years have demonstrated that polymorphonuclear neutrophils (PMN) also have the ability to synthesize and release immunoregulatory cytokines. Here, Marco Cassatella describes novel facets of the regulation of cytokine production by PMN that highlight the involvement of of PMN in cell-cytokine crosstalk.