Prevention and Treatment of Colorectal Cancer by Natural Agents From Mother Nature.
Prevention and Treatment of Colorectal Cancer by Natural Agents From Mother Nature.
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DOI：
10.1007/s11888-012-0154-1
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发表时间：
2013-03-01
影响因子：
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通讯作者：
Guha, Sushovan
中科院分区：
文献类型：
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作者：
Aggarwal, Bharat;Prasad, Sahdeo;Sung, Bokyung;Krishnan, Sunil;Guha, Sushovan
结直肠癌（CRC）是美国第三大最常见的诊断癌症，仅次于肺癌和乳腺癌/前列腺癌。虽然美国的CRC发病率是世界上最高的（约52/100，000），但其在印度的发病率是最低的（约7/100，000），这表明生活方式因素可能在疾病的发展中起作用。虽然肥胖，过量饮酒，高热量饮食和缺乏体力活动会促进这种癌症，但有证据表明，含有叶酸，硒，维生素D，膳食纤维，大蒜，牛奶，钙，香料，蔬菜和水果的食物对人类CRC具有保护作用。已经确定了许多来自“自然界”（也称为“营养品”）的具有预防和治疗CRC潜力的药物。最重要的发现涉及化合物，如小豆蔻素、雷公藤红素、姜黄素、鱼藤素、薯蓣皂苷元、百里醌、生育三烯酚、熊果酸和zerumbone。与药物不同，这些药物调节多个靶点，包括转录因子、生长因子、肿瘤细胞存活因子、炎症通路以及与CRC密切相关的侵袭和血管生成。我们描述了这些饮食剂抑制培养中人CRC细胞生长和抑制动物模型中肿瘤生长的潜力。我们还描述了临床试验中，这些药物已被测试的疗效在人类。由于它们的安全性和可负担性，这些营养保健品为CRC的治疗提供了一个新的机会，CRC是一种具有“老年”解决方案的“老年”疾病。
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States after cancers of the lung and the breast/prostate. While the incidence of CRC in the United States is among the highest in the world (approximately 52/100,000), its incidence in countries in India is among the lowest (approximately 7/100,000), suggesting that lifestyle factors may play a role in development of the disease. Whereas obesity, excessive alcohol consumption, a high-calorie diet, and a lack of physical activity promote this cancer, evidence indicates that foods containing folates, selenium, Vitamin D, dietary fiber, garlic, milk, calcium, spices, vegetables, and fruits are protective against CRC in humans. Numerous agents from “mother nature” (also called “nutraceuticals,”) that have potential to both prevent and treat CRC have been identified. The most significant discoveries relate to compounds such as cardamonin, celastrol, curcumin, deguelin, diosgenin, thymoquinone, tocotrienol, ursolic acid, and zerumbone. Unlike pharmaceutical drugs, these agents modulate multiple targets, including transcription factors, growth factors, tumor cell survival factors, inflammatory pathways, and invasion and angiogenesis linked closely to CRC. We describe the potential of these dietary agents to suppress the growth of human CRC cells in culture and to inhibit tumor growth in animal models. We also describe clinical trials in which these agents have been tested for efficacy in humans. Because of their safety and affordability, these nutraceuticals provide a novel opportunity for treatment of CRC, an “old age” disease with an “age old” solution.