Quantifying pediatric neuro-oncology risk factors: Development of the neurological predictor scale
Quantifying pediatric neuro-oncology risk factors: Development of the neurological predictor scale
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DOI：
10.1177/0883073807309241
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发表时间：
2008-04-01
影响因子：
1.9
通讯作者：
Krawiecki, Nicolas
中科院分区：
文献类型：
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作者：
Micklewright, Jackie L.;King, Tricia Z.;Krawiecki, Nicolas
儿科神经肿瘤学研究人员面临着量化肿瘤和治疗相关风险因素对儿童结局影响的方法学挑战。神经学预测量表是作为儿童暴露于危险因素的累积指数而开发的。在25例异质性脑肿瘤儿童样本中探讨了神经预测量表的临床实用性。与预期一致，一系列回归分析表明，神经预测量表显著预测了复合智力功能（r（2）= 0.21，V < .05），短期记忆（r（2）= 0.16，p = .05）和抽象视觉推理能力（r（2）= 0.28，p < .05）。除了化疗，神经预测量表占了显着的量的变化，在儿童智力功能以上，超出个别检查的变量。神经学预测量表可用于快速量化与小儿脑肿瘤诊断相关的累积风险因素。
Pediatric neuro-oncology researchers face methodological challenges associated with quantifying the influence of tumor and treatment-related risk factors on child outcomes. The Neurological Predictor Scale was developed to serve as a cumulative index of a child's exposure to risk factors. The clinical utility Of the Neurological Predictor Scale was explored in a sample of 25 children with heterogeneous brain tumors. Consistent with expectation, a series of regression analyses demonstrated that the Neurological Predictor Scale significantly predicted composite intellectual functioning (r(2) = 0.21, V < .05), short-term memory (r(2) = 0.16, p = .05), and abstract visual reasoning abilities (r(2) = = 0.28, p < .05). With the exception of chemotherapy, the Neurological Predictor Scale accounted for a significant amount of the variance in child intellectual functioning above and beyond individually examined variables. The Neurological Predictor Scale can be used to quickly quantify the cumulative risk factors associated with pediatric brain tumor diagnoses.