Polymorphisms in Folate-Related Enzyme Genes in Idiopathic Infertile Brazilian Men
Polymorphisms in Folate-Related Enzyme Genes in Idiopathic Infertile Brazilian Men
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DOI：
10.1177/1933719111411729
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发表时间：
2011-12-01
影响因子：
2.9
通讯作者：
Barbosa, Caio P.
中科院分区：
文献类型：
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作者：
Gava, Marcello M.;Kayaki, Erika A.;Barbosa, Caio P.
该研究的目的是分析亚甲基四氢叶酸还原酶（MTHFR）、甲硫氨酸合酶还原酶（MTRR）和甲硫氨酸合酶（MTR）多态性在特发性不育巴西男性和生育男性中的分布。病例对照研究包括 133 名患有非梗阻性无精症 ([NOA] n = 55) 或严重少精症 ([SO] n = 78) 的特发性不育巴西男性和作为对照的 173 名生育男性。 MTHFR C677T、A1298C 和 G1793A；港铁A66G；通过定量聚合酶链反应（qPCR）研究了MTR A2756G 多态性。对结果进行统计分析并得出P值
The aim of the study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), and methionine synthase (MTR) polymorphisms in idiopathic infertile Brazilian men and fertile men. Case-control study comprising 133 idiopathic infertile Brazilian men with nonobstructive azoospermia ([NOA] n = 55) or severe oligozoospermia ([SO] n = 78) and 173 fertile men as controls. MTHFR C677T, A1298C, and G1793A; MTRR A66G; and MTR A2756G polymorphisms were studied by quantitative polymerase chain reaction (qPCR). The results were analyzed statistically and a P value