Effects of chewing in working memory processing
Effects of chewing in working memory processing
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DOI：
10.1016/j.neulet.2008.03.033
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发表时间：
2008-05-09
影响因子：
2.5
通讯作者：
Onozuka, Minoru
中科院分区：
文献类型：
--
作者：
Hirano, Yoshiyuki;Obata, Takayuki;Onozuka, Minoru
人们普遍认为，咀嚼对成套测试中与记忆有关的认知表现方面产生了增强作用。此外，最近的研究表明，咀嚼与大脑各个区域的激活有关，包括前额叶皮层。然而，很少有人知道咀嚼影响的认知性能和大脑中特定区域的神经元活动之间的关系。因此，我们研究了咀嚼对大脑神经元活动的影响，在工作记忆任务中使用功能磁共振成像。受试者在连续执行两回或三回（n-back）工作记忆任务之间咀嚼口香糖，没有气味和味道成分。在n-back任务中，咀嚼增加了背外侧前额叶皮层中额中回（Brodmann区域9和46）的BOLD信号。此外，在咀嚼试验后的n-back任务中，右侧运动前皮质、楔前叶、丘脑、海马和下顶叶的激活更为显著。这些结果表明，咀嚼可以加速或恢复工作记忆的过程，除了诱导通过咀嚼运动的唤醒水平的改善。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
It has been generally suggested that chewing produces an enhancing effect on cognitive performance-related aspects of memory by the test battery. Furthermore, recent studies have shown that chewing is associated with activation of various brain regions, including the prefrontal cortex. However, little is known about the relation between cognitive performances affected by chewing and the neuronal activity in specified regions in the brain. We therefore examined the effects of chewing on neuronal activities in the brain during a working memory task using fMRI. The subjects chewed gum, without odor and taste components, between continuously performed two- or three-back (n-back) working memory tasks. Chewing increased the BOLD signals in the middle frontal gyrus (Brodmann's areas 9 and 46) in the dorsolateral prefrontal cortex during the n-back tasks. Furthermore, there were more prominent activations in the right premotor cortex, precuneus, thalamus, hippocampus and inferior parietal lobe during the n-back tasks after the chewing trial. These results suggest that chewing may accelerate or recover the process of working memory besides inducing improvement in the arousal level by the chewing motion. (C) 2008 Elsevier Ireland Ltd. All rights reserved.