Circulating adropin concentrations in pediatric obstructive sleep apnea: potential relevance to endothelial function.
Circulating adropin concentrations in pediatric obstructive sleep apnea: potential relevance to endothelial function.
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小儿阻塞性睡眠呼吸暂停中循环的adropin浓度：与内皮功能的潜在相关性。
DOI：
10.1016/j.jpeds.2013.05.040
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Bandla HP
中科院分区：
文献类型：
--
作者：
Gozal D;Kheirandish-Gozal L;Bhattacharjee R;Molero-Ramirez H;Tan HL;Bandla HP
Adropin是最近发现的一种肽，具有重要的代谢和心血管功能，其水平在阻塞性睡眠呼吸暂停（OSA）患者中较低，特别是与内皮功能障碍相关时。年龄、性别和种族相匹配的儿童（平均年龄：7.2±1.4岁）根据夜间睡眠研究中OSA的存在和使用改良充血试验的闭塞后最大再灌注时间（Tmax>45秒）被纳入三组之一。使用商业ELISA试剂盒测定血浆肾上腺素水平。在对照组中，平均早晨肾上腺素水平为7.4 ng/ml，（95%可信区间：5.2-16.3 ng/ml）伴有内皮功能异常的OSA儿童（OSA+/EF+）的Adropin水平显著降低（2.7±1.1 ng/ml，n=35）与匹配对照组相比（7.6±1.4 ng/ml; n=35; p<0.001），以及OSA和正常内皮功能的儿童（OSA+/EF-：5.8±1.5 ng/ml，n=47; p<0.001）。血浆Adropin <4.2 ng/ml可靠地预测内皮功能状态，但个体Adropin水平与年龄、BMI-z评分、阻塞性呼吸暂停低通气指数（AHI）或最低SpO 2无显著相关性。对一组OSA患儿（n=22）行扁桃体腺样体切除术后的Adropin水平进行了评估，结果显示OSA+/EF+升高（2.5±1.4 ng/ml至6.4±1.9 ng/ml，n=14; p<0.01），但OSA+EF−保持不变（5.7±1.3 ng/ml至6.4±1.1 ng/ml，n=8; p>0.05）。当存在内皮功能障碍时，儿童OSA的血浆肾上腺素水平降低，并在腺样体扁桃体切除术后恢复至正常值。Adropin循环水平的评估可以提供一个可靠的指标血管损伤的情况下，OSA的儿童。
To test the hypothesis that levels of adropin, a recently discovered peptide that displays important metabolic and cardiovascular functions, are lower in obstructive sleep apnea (OSA), especially when associated with endothelial dysfunction. Age-, sex- and ethnicity-matched children (mean age: 7.2±1.4 years) were included into one of three groups based on the presence of OSA in an overnight sleep study, and on the time to post-occlusive maximal reperfusion (Tmax>45 sec) with a modified hyperemic test. Plasma adropin levels were assayed using a commercial ELISA kit. Among controls, mean morning adropin levels were 7.4 ng/ml (95% confidence intervals: 5.2–16.3 ng/ml) OSA children with abnormal endothelial function (OSA+/EF+) had significantly lower adropin levels (2.7±1.1 ng/ml, n=35) compared with matched controls (7.6±1.4 ng/ml; n=35; p<0.001), and to children with OSA and normal endothelial function (OSA+/EF−: 5.8±1.5 ng/ml, n=47; p<0.001). Plasma adropin <4.2 ng/ml reliably predicted endothelial functional status, but individual adropin levels were not significantly correlated with age, BMI-z score, obstructive apnea-hypopnea index (AHI) or nadir SpO2. Adropin levels were assessed after adenotonsillectomy in a subset of children with OSA (n=22), and showed increases in OSA+/EF+ (2.5±1.4 ng/ml to 6.4±1.9 ng/ml, n=14; p<0.01) but remained unchanged in OSA+EF− (5.7±1.3 ng/ml to 6.4±1.1 ng/ml, n=8; p>0.05). Plasma adropin levels are reduced in pediatric OSA when endothelial dysfunction is present, and return to within normal values after adenotonsillectomy. Assessment of adropin circulating levels may provide a reliable indicator of vascular injury in the context of OSA on children.
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影响因子：
29
作者：
Kumar KG;Trevaskis JL;Lam DD;Sutton GM;Koza RA;Chouljenko VN;Kousoulas KG;Rogers PM;Kesterson RA;Thearle M;Ferrante AW Jr;Mynatt RL;Burris TP;Dong JZ;Halem HA;Culler MD;Heisler LK;Stephens JM;Butler AA
通讯作者：
Butler AA
影响因子：
8
作者：
Montgomery-Downs, HE;O'Brien, LM;Gozal, D
通讯作者：
Gozal, D
影响因子：
9.6
作者：
Muzumdar, Hiren V.;Sin, Sanghun;Arens, Raanan
通讯作者：
Arens, Raanan
影响因子：
9.6
作者：
Kheirandish-Gozal, Leila;Khalyfa, Abdelnaby;Wang, Yang
通讯作者：
Wang, Yang
影响因子：
2.4
作者：
Bhattacharjee, Rakesh;Alotaibi, Wadha H.;Gozal, David
通讯作者：
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