Bacterial vaginosis: identifying research gaps proceedings of a workshop sponsored by DHHS/NIH/NIAID.
Bacterial vaginosis: identifying research gaps proceedings of a workshop sponsored by DHHS/NIH/NIAID.
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DOI：
10.1097/olq.0b013e3181fbbc95
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发表时间：
2010-12
影响因子：
3.1
通讯作者：
Fredricks DN
中科院分区：
文献类型：
--
作者：
Marrazzo JM;Martin DH;Watts DH;Schulte J;Sobel JD;Hillier SL;Deal C;Fredricks DN
GROUNDBV是常见的，并始终与不良症状和生殖道结果相关。BV是育龄女性中最常见的阴道感染形式，影响8%至23%，也是促使女性寻求医疗护理的阴道症状的最常见病因。1症状BV，约占所有病例的60%，通常导致异常阴道分泌物，数量增加，通常有恶臭。分泌物部分由正常阴道粘蛋白凝胶的降解引起，其通过BV相关细菌（特别是革兰氏阴性厌氧菌）产生的粘蛋白降解酶有效地进行。2这种气味通常被描述为“鱼腥味”，是由厌氧细菌代谢产生的胺挥发而产生的，是这种疾病的特征。
BACKGROUNDBV is common, and consistently associated with adverse symptoms and reproductive tract outcomes. BV is the most prevalent form of vaginal infection in women of reproductive age, affecting 8% to 23%, and is the most common etiology of vaginal symptoms prompting women to seek medical care. 1 Symptomatic BV, which accounts for approximately 60% of all cases, typically causes abnormal vaginal discharge that is increased in amount and often malodorous. The discharge results in part from degradation of the normal vaginal mucin gel, which is efficiently performed by mucin-degrading enzymes produced by BV-associated bacteria (particularly Gram-negative anaerobes). 2 The odor, usually described as “fishy,” is derived from volatilization of the amines produced by the metabolism of anaerobic bacteria that characterize this disorder.