Enhancement of apomorphine-induced climbing in mice by reversible and irreversible narcotic antagonist drugs.
Enhancement of apomorphine-induced climbing in mice by reversible and irreversible narcotic antagonist drugs.
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可逆和不可逆麻醉拮抗剂药物增强阿扑吗啡诱导的小鼠攀爬。
DOI：
10.1016/0024-3205(81)90417-3
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
T. S. Lucas
中科院分区：
文献类型：
--
作者：
R. Quock;T. S. Lucas
阿扑吗啡在小鼠中产生了一种典型的攀爬综合征。用增加剂量的可逆性麻醉剂拮抗剂纳洛酮预处理小鼠导致这种活性的剂量相关增强。给小鼠中枢微量注射不可逆的麻醉性拮抗剂药物氯纳替拉明，预处理后14天，阿扑吗啡诱导的攀爬也显著增强。这些数据表明，可逆和不可逆类型的麻醉剂拮抗剂药物能够增强小鼠中的多巴胺能药物作用。
Apomorphine produced a characteristic climbing syndrome in mice. Pretreatment of mice with increasing doses of the reversible narcotic antagonist naloxone resulted in a dose-related enhancement of this activity. Central microinjection of mice with the irreversible narcotic antagonist drug chlornaltrexamine also resulted in significant potentiation of apomorphine-induced climbing for up to fourteen days following pretreatment. These data indicate that narcotic antagonist drugs of both reversible and irreversible types are capable of enhancing this dopaminergic drug effect in mice.