Functional renal reserve capacity in different stages of chronic kidney disease
Functional renal reserve capacity in different stages of chronic kidney disease
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DOI：
10.1111/j.1440-1797.2010.01291.x
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发表时间：
2010-04-01
期刊：
影响因子：
2.5
通讯作者：
Ora, Manish
中科院分区：
文献类型：
--
作者：
Barai, Sukanta;Gambhir, Sanjay;Ora, Manish
目的：已发表的关于健康成人和慢性肾脏病（CKD）不同阶段肾功能储备（RR）可用性程度的报告存在冲突。本研究的目的是确定在不同阶段的CKD.Methods的RR：基线肾小球滤过率（GFR）和“刺激GFR”后的氨基酸输液在25名志愿者和100例患者在不同阶段的CKD通过测量Tc 99 m二乙基三胺五乙酸的血浆清除率。结果健康对照组的平均肾储备为23.4%，CKD 1期为19.08%，CKD 2期为15.4%，CKD 3期为8.9%，CKD 4期为6.7%，CKD 4期为6.7%，CKD 1期为19.08%，CKD 2期为15.4%，CKD 3期为8.9%，CKD 4期为6.7%，CKD 4期为6.7%。然而，RR也可能完全耗尽，即使基础GFR正常或略有下降。即使GFR水平高达15 mL/min，肾脏也可能保留一些RR。
Aim:There is conflict in published reports on the extent of availability of the functional renal reserve (RR) in healthy adults and in various stages of chronic kidney disease (CKD). The aim of the present study was to determine the RR in various stages of CKD.Methods:Baseline glomerular filtration rate (GFR) and 'stimulated GFR' following amino acid infusion were measured in 25 volunteers and 100 patients at various stages of CKD by measuring plasma clearance of Tc99m diethyl triamine pentaacetic acid. Any obtained difference between stimulated and basal GFR was considered as RR and expressed as percentage.ResultsThe mean renal reserve was 23.4% in the healthy control group, 19.08% in CKD stage 1, 15.4% in CKD stage 2, 8.9% in CKD stage 3 and 6.7% in CKD stage 4, respectively.Conclusion:Renal reserve falls relentlessly with progression of CKD from 23.4% in normal to 6.7% in stage 4 CKD. However, RR may also get completely exhausted even with a normal or with a minimal decline basal GFR. Kidneys may retain some RR even up to the GFR level of 15 mL/min.