Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp SCSIO F063
Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp SCSIO F063
复制标题
来自海洋源性真菌曲霉属 SCSIO F063 的卤化蒽醌
DOI：
10.1021/np3002699
复制
发表时间：
2012-07-01
影响因子：
5.1
通讯作者：
Ju, Jianhua
中科院分区：
文献类型：
--
作者：
Huang, Hongbo;Wang, Fazuo;Ju, Jianhua
针对海洋来源真菌Aspergillus sp. SCSIO F063的代谢组学研究揭示了7种新的与阿维菌素相关的氯化蒽醌（1-7），以及使用含海盐的马铃薯葡萄糖肉汤发酵该真菌时的5种已知类似物（11-15）。通过向发酵液中加入溴化钠，从真菌菌丝体中分离得到两个新的溴代蒽醌（8，9）和一个新的非卤代蒽醌（10）。通过广泛的光谱分析（包括MS、ID和2D NMR数据）阐明了它们的结构。其中一种代谢产物6-O-甲基-7-氯代阿维菌素（2）对三种人肿瘤细胞系SF 268、MCF-7和NCI-H460显示出抑制活性，IC 50值分别为7.11、6.64和7.42 μ M。
Metabolomic investigations focusing on the marine-derived fungus Aspergillus sp. SCSIO F063 have unveiled seven new chlorinated anthraquinones (1-7) related to averantin, together with five known analogues (11-15) when the fungus was fermented using sea salt-containing potato dextrose broth. Through the addition of sodium bromide to the broth, two new brominated anthraquinones (8, 9) and one new nonhalogenated anthraquinone (10) were obtained from the fungal mycelia. Their structures were elucidated by extensive spectroscopic analyses including MS and ID and 2D NMR data One metabolite, 6-O-methyl-7-chloroaveratin (2), displayed inhibition activity against three human tumor cell lines, SF 268, MCF-7, and NCI-H460, with IC50 values of 7.11, 6.64, and 7.42 mu M, respectively.