Effect of plant growth regulators on the biosynthesis of vinblastine, vindoline and catharanthine in Catharanthus roseus
Effect of plant growth regulators on the biosynthesis of vinblastine, vindoline and catharanthine in Catharanthus roseus
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DOI：
10.1007/s10725-009-9429-1
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发表时间：
2010-03-01
影响因子：
4.2
通讯作者：
Tang, Kexuan
中科院分区：
文献类型：
--
作者：
Pan, Qifang;Chen, Yu;Tang, Kexuan
长春花属植物长春花碱和长春新碱属于萜类吲哚生物碱，是一种著名的药用植物。人们对其次生代谢途径的原理进行了大量的研究，以调节生物碱的生物合成。本文研究了不同植物生长调节剂在长春花花期短期内对长春花碱、长春花碱和长春花碱生物合成的影响。水杨酸和乙烯利处理显著增加了长春花碱、长春花碱和长春花碱的积累，而脱落酸和赤霉酸对这三种重要生物碱的积累有强烈的负面影响。茉莉酸甲酯对这些有价值的生物碱的产生影响不大。氯氰菊酯显著促进了长春花碱的积累，但显著降低了长春花碱和长春花碱的含量。
Catharanthuse roseus is a well-known medicinal plant for its two valuable anticancer compounds: vinblastine and vincristine, which belongs to terpenoid indole alkaloids. Great efforts have been made to study the principles of its secondary metabolic pathways to regulate the alkaloids biosynthesis. In this article, different plant growth regulators were shortly applied to Catharanthus roseus plants during the blooming period to study their effects on the biosynthesis of vinblastine, vindoline and catharanthine. Salicylic acid and ethylene (ethephon) treatments resulted in a significant increase of vinblastine, vindoline and catharanthine while abscisic acid and gibberellic acid had a strongly negative influence on the accumulation of the three important alkaloids. Methyl jasmonate showed no great effect on the production of these valuable alkaloids. Chlormequat chloride highly enhanced the accumulation of vinblastine but greatly decreased the contents of vindoline and catharanthine.