Marriage Strategy of Structure and Composition Designs for Intensifying Ultrasound & MR & CT Trimodal Contrast Imaging.
Marriage Strategy of Structure and Composition Designs for Intensifying Ultrasound & MR & CT Trimodal Contrast Imaging.
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DOI：
10.1021/acsami.5b04999
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发表时间：
2015-08
影响因子：
9.5
通讯作者：
Kun Zhang;Hangrong Chen;Pei Li;Xiaowan Bo;Xiao-Long Li;Z. Zeng;Huixiong Xu
中科院分区：
文献类型：
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作者：
Kun Zhang;Hangrong Chen;Pei Li;Xiaowan Bo;Xiao-Long Li;Z. Zeng;Huixiong Xu
尽管人们在多模式成像探头的设计上付出了很大的努力，但几乎所有的纳米异构体的设计原则都服从于简单的积木组装，导致制备过程复杂，能力打折，即1+1和1；2。在本报告中，建立了一种新的设计策略，将结构设计和成分设计结合起来，使每个积木的成像能力最大化，最终实现1+1≥2。此外，以高效超声-MR-CT三峰造影剂为模型，验证了纳米粒子诱导的非线性散射和振荡型结构诱导的二次散射增强超声成像，以及有利于增强MR成像和CT成像的Au原子中的Mn(2+)顺磁中心和“核-星”结构的均匀分布，实现了结构设计的优化。重要的是，选定的组分二氧化硅、Au和MnO具有良好的生物相容性，体现了成分设计与上述结构优化的结合策略。在体内的评价中，这种生物相容的三峰探针在体内增强CT、MR和US成像方面表现出优异的性能，特别是通过PEI正电修饰促进更多的探针留在肿瘤中。更重要的是，作为一种通用的设计策略，构建这种US、MR和CT三模成像探头所涉及的原则对其他材料基多模成像探头的设计具有很大的指导作用。
Despite great efforts having been devoted to the design of multimodal imaging probe, almost all design principles of nanotheranostic agents subordinate to simple assemblies of building blocks, resulting in complex preparation process and discounted ability, that is, 1 + 1 < 2. In this report, a novel design strategy, marriage of structure design and composition design that can maximize imaging ability of each building block, ultimately achieving 1 + 1 ≥ 2, has been established. Moreover, a high-efficient ultrasound (US) & MR & CT trimodal contrast agent acts as model to instantiate this design strategy, wherein nanoparticles-induced nonlinear scattering and rattle-type structure-induced double scattering enhancing US imaging, and uniform distribution of Mn(2+) paramagentic centers and "core-satellite" structure of Au atoms favoring enhanced MR imaging and CT imaging, respectively have been validated, achieving optimization of structure design. Importantly, the selected components, silica, Au and MnO are endowed with excellent biocompatibility, displaying the marriage strategy of composition design with aforementioned structure optimization. In in vivo evaluations, such a biocompatible trimodal probe is demonstrated of excellent performance in intensifying CT, MR and US imaging in vivo, especially after positively charged modification by PEI promoting more probes retained in tumor. More importantly, as a universal design strategy, the involved principles in constructing such a US&MR&CT trimodal imaging probe promise great potentials in guiding designs of other materials-based multimodal imaging probe.