Neurovascular responses to mental stress in prehypertensive humans.
Neurovascular responses to mental stress in prehypertensive humans.
复制标题
高血压前期人群对精神压力的神经血管反应。
DOI：
10.1152/japplphysiol.00912.2010
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Carter,JasonR
中科院分区：
文献类型：
--
作者：
Schwartz,ChristopherE;Durocher,JohnJ;Carter,JasonR
神经血管对精神压力的反应与包括高血压在内的几种心血管疾病有关。平均动脉压（MAP），肌肉交感神经活动（MSNA），前臂血管反应的精神压力是有据可查的正常血压（NT）的科目，但在高血压前期（PHT）的科目的反应仍不清楚。我们测试了这一假设，PHT会引起更显着的增加MAP在精神压力通过增强MSNA和钝前臂血管传导（FVC）。我们检查了17名PHT（收缩压120-139和/或舒张压80-89 mmHg; 22 ± 1年）和18名NT（收缩压< 120和舒张压< 80 mmHg; 23 ± 2年）受试者。心率，MAP，MSNA，FVC，和小腿血管传导率在5分钟的基线和5分钟的精神应激（心算）。心理应激使两组MAP和FVC均升高，但PHT组MAP升高幅度更大（Δ 10 ± 1 vs. Δ14 ± 1 mmHg;P< 0.05），FVC升高幅度更小（Δ95 ± 14 vs. Δ37 ± 8%;P< 0.001）。在NT和PHT受试者中，精神应激分别引起MSNA（Δ7 ± 2 vs. Δ6 ± 2 bursts/min）、心率（Δ21 ± 3 vs. Δ18 ± 3 beats/min）和小腿血管传导性（Δ29 ± 10 vs. Δ19 ± 5%）相似的增加。总之，精神应激可增强PHT受试者的升压反应。这种增强似乎与前臂血管改变有关，但与MSNA对精神压力的反应无关。
Neurovascular responses to mental stress have been linked to several cardiovascular diseases, including hypertension. Mean arterial pressure (MAP), muscle sympathetic nerve activity (MSNA), and forearm vascular responses to mental stress are well documented in normotensive (NT) subjects, but responses in prehypertensive (PHT) subjects remain unclear. We tested the hypothesis that PHT would elicit a more dramatic increase of MAP during mental stress via augmented MSNA and blunted forearm vascular conductance (FVC). We examined 17 PHT (systolic 120–139 and/or diastolic 80–89 mmHg; 22 ± 1 yr) and 18 NT (systolic < 120 and diastolic < 80 mmHg; 23 ± 2 yr) subjects. Heart rate, MAP, MSNA, FVC, and calf vascular conductance were measured during 5 min of baseline and 5 min of mental stress (mental arithmetic). Mental stress increased MAP and FVC in both groups, but the increases in MAP were augmented (Δ 10 ± 1 vs. Δ14 ± 1 mmHg;P< 0.05), and the increases in FVC were blunted (Δ95 ± 14 vs. Δ37 ± 8%;P< 0.001) in PHT subjects. Mental stress elicited similar increases in MSNA (Δ7 ± 2 vs. Δ6 ± 2 bursts/min), heart rate (Δ21 ± 3 vs. Δ18 ± 3 beats/min), and calf vascular conductance (Δ29 ± 10 vs. Δ19 ± 5%) in NT and PHT subjects, respectively. In conclusion, mental stress elicits an augmented pressor response in PHT subjects. This augmentation appears to be associated with altered forearm vascular, but not MSNA, responses to mental stress.