Atrial natriuretic peptide protects against acute ischemic renal failure in the rat.
Atrial natriuretic peptide protects against acute ischemic renal failure in the rat.
复制标题
心钠素可预防大鼠急性缺血性肾衰竭。
DOI：
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发表时间：
1987
影响因子：
15.9
通讯作者：
Adriano Patemostro
中科院分区：
文献类型：
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作者：
S. Shaw;P. Weidmann;Jurg Hodler;Arthur Zimmermann;Adriano Patemostro
由于其增加肾小球滤过、拮抗血管收缩剂的作用和产生血管舒张的能力，在双侧或单侧肾完整的Sprague-Dawley大鼠中评价α-人心房利钠肽（α-hANP）在由45 - 60分钟肾动脉闭塞诱导的实验性缺血性肾衰竭中的潜在有益作用。缺血后，肾内输注α-hANP 4小时可使双侧和单侧完整动物的14C-菊粉清除率分别从0.05 +/-0.006和0.05 +/-0.01 ml/min/100 g恢复至0.314 +/-0.04和0.25 +/-0.01 ml/min/100 g（P <0.001，n = 8），而正常值为0.49 +/-0.023 ml/min/100 g。在组织学上，由于4小时α-hANP输注，髓质充血逐渐减少，小管内细胞脱落和粒细胞边缘化得到预防，因此在24和48小时后，组织的组织学外观基本正常。结果表明，肾缺血后4h肾内输注α-hANP可保持肾小球滤过率，减轻肾组织损伤。
Because of its ability to increase glomerular filtration, antagonize the actions of vasoconstrictors, and produce vasodilation, alpha human atrial natriuretic peptide (alpha-hANP) was evaluated for its potentially beneficial effects in experimental ischemic renal failure induced by 45-60 min of renal artery occlusion in bilaterally or unilaterally renally intact Sprague-Dawley rats. After ischemia, a 4-h intrarenal infusion of alpha-hANP restored 14C-inulin clearances in bilaterally and unilaterally intact animals from 0.05 +/- 0.006 and 0.05 +/- 0.01 ml/min per 100 g to 0.314 +/- 0.04 and 0.25 +/- 0.01 ml/min per 100 g, respectively (P less than 0.001, n = 8), compared with normal values of 0.49 +/- 0.023 ml/min per 100 g. Histologically, there was a progressive decrease in medullary hyperemia and prevention of intratubular cell shedding and granulocyte margination as a result of the 4-h alpha-hANP infusion such that after 24 and 48 h the histological appearance of the tissue was essentially normal. The results show that a 4-h intrarenal infusion of alpha-hANP after renal ischemia can preserve glomerular filtration rate and reduce renal tissue damage.
影响因子：
19.6
作者：
SHEMESH, O;GOLBETZ, H;MYERS, BD
通讯作者：
MYERS, BD